GSK3 Degrader PT-65 is a highly potent and selective GSK3 degrader for the treatment of Alzheimer's Disease (GSK3α DC50 = 28.3 nM and GSK3β DC50 = 34.2 nM in SH-SY5Y cells). PT-65 was found to be able to successfully suppress tau hyperphosphorylation for both in cell and invivo models of Alzheimer's Disease.
MedKoo Cat#: 130093
Name: GSK3 Degrader PT-65
CAS#: 2721998-87-2
Chemical Formula: C51H63N13O12S
Exact Mass: 1081.4440
Molecular Weight: 1082.20
Elemental Analysis: C, 56.60; H, 5.87; N, 16.83; O, 17.74; S, 2.96
The following data is based on the product molecular weight 1,082.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
