Synonym
Opc 15161; Opc-15161; Opc15161
IUPAC/Chemical Name
2(1H)-Pyrazinone, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-, 4-oxide
InChi Key
AFTLYEDBVFGRNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N3O3/c1-11(2)8-16-17(22)20-15(18(24-3)21(16)23)9-12-10-19-14-7-5-4-6-13(12)14/h4-7,10-11,19H,8-9H2,1-3H3,(H,20,22)
SMILES Code
O=C1C(CC(C)C)=[N+]([O-])C(OC)=C(CC2=CNC3=C2C=CC=C3)N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
327.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saika S, Yamanaka O, Kawashima Y, Ohkawa K, Ohnishi Y, Ooshima A, Kimura M, Nakano Y, Kao WW. OPC-15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro. Curr Eye Res. 1998 Sep;17(9):933-40. PubMed PMID: 9746441.
2: Sanaka T, Nakano Y, Nishimura H, Shinobe M, Higuchi C, Omata M, Nihei H, Sugino N. Therapeutic effect of a newly developed antioxidative agent (OPC-15161) on experimental immune complex nephritis. Nephron. 1997;76(3):315-22. PubMed PMID: 9226233.
3: Sugawara H, Ueno T, Torimura T, Inuzuka S, Tanikawa K. Inhibitory effect of OPC-15161, a component of fungus Thielavia minor, on proliferation and extracellular matrix production of rat cultured hepatic stellate cells. J Cell Physiol. 1998 Mar;174(3):398-406. PubMed PMID: 9462702.
4: Ozawa T, Nakano Y. The radical scavenging abilities of a new anti-nephritic drug, OPC-15161. Biochem Mol Biol Int. 1996 Feb;38(2):231-8. PubMed PMID: 8850518.
5: Nakano Y, Kawaguchi T, Sumitomo J, Takizawa T, Uetsuki S, Sugawara M, Kido M. Novel inhibitors of superoxide anion generation, OPC-15160 and OPC-15161. Taxonomy, fermentation, isolation, physico-chemical properties, biological characteristics and structure determination. J Antibiot (Tokyo). 1991 Jan;44(1):52-8. PubMed PMID: 1848216.
6: Hamada N, Nagase M. In vivo effect of OPC15161, a superoxide scavenger, on anti-Thy1 nephritis. Eur J Pharmacol. 1996 Dec 12;317(1):123-8. PubMed PMID: 8982728.
