Synonym
AE-92686, AE92686, AE 92686
IUPAC/Chemical Name
(1,2,4)Triazolo(1,5-a)pyridine, 5,8-dimethyl-2-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)-
InChi Key
AZOOBRKWMCUHJL-UHFFFAOYSA-N
InChi Code
1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3
SMILES Code
Cc1ccc(C)n2nc(CCc3nc(cn3C)c4ccccc4)nc12
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
331.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Persson J, Szalisznyó K, Antoni G, Wall A, Fällmar D, Zora H, Bodén R. Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study. Eur Arch Psychiatry Clin Neurosci. 2019 May 22. doi: 10.1007/s00406-019-01021-0. [Epub ahead of print] PubMed PMID: 31119377.
2: Bodén R, Persson J, Wall A, Lubberink M, Ekselius L, Larsson EM, Antoni G. Striatal phosphodiesterase 10A and medial prefrontal cortical thickness in patients with schizophrenia: a PET and MRI study. Transl Psychiatry. 2017 Mar 7;7(3):e1050. doi: 10.1038/tp.2017.11. PubMed PMID: 28267149; PubMed Central PMCID: PMC5416662.
3: Yang KC, Stepanov V, Amini N, Martinsson S, Takano A, Nielsen J, Bundgaard C, Bang-Andersen B, Grimwood S, Halldin C, Farde L, Finnema SJ. Characterization of [(11)C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain. Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):308-320. doi: 10.1007/s00259-016-3544-9. Epub 2016 Nov 5. PubMed PMID: 27817159; PubMed Central PMCID: PMC5215309.
4: Kehler J, Kilburn JP, Estrada S, Christensen SR, Wall A, Thibblin A, Lubberink M, Bundgaard C, Brennum LT, Steiniger-Brach B, Christoffersen CT, Timmermann S, Kreilgaard M, Antoni G, Bang-Andersen B, Nielsen J. Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain. J Nucl Med. 2014 Sep;55(9):1513-8. doi: 10.2967/jnumed.114.140178. Epub 2014 Jul 3. PubMed PMID: 24994928.
