LBM-415 | CAS#478913-91-6 | PDF Inhibitor

MedKoo Cat#: 525430 | Name: LBM-415

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LBM-415 is the first member of the peptide deformylase (PDF) inhibitor class. It is being developed for clinical trials as a parenteral and oral agent for treatment of community-acquired respiratory tract disease and serious infections caused by antimicrobial-resistant gram-positive cocci.

Chemical Structure

LBM-415

CAS#478913-91-6

Theoretical Analysis

MedKoo Cat#: 525430

Name: LBM-415

CAS#: 478913-91-6

Chemical Formula: C18H25FN4O5

Exact Mass: 396.1809

Molecular Weight: 396.41

Elemental Analysis: C, 54.54; H, 6.36; F, 4.79; N, 14.13; O, 20.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LBM-415; LBM 415; LBM415; NVP-PDF-713.

IUPAC/Chemical Name

(2S)-1-((2R)-2-((Formylhydroxyamino)methyl)hexanoyl)pyrrolidine-2-carboxylic acid N-(5-fluoro-1-oxopyridin-2-yl)amide

InChi Key

LYPFVIYNUQCDPM-HIFRSBDPSA-N

InChi Code

InChI=1S/C18H25FN4O5/c1-2-3-5-13(10-21(27)12-24)18(26)22-9-4-6-15(22)17(25)20-16-8-7-14(19)11-23(16)28/h7-8,11-13,15,27H,2-6,9-10H2,1H3,(H,20,25)/t13-,15+/m1/s1

SMILES Code

O=C([C@H]1N(C([C@@H](CN(C=O)O)CCCC)=O)CCC1)NC2=CC=C(F)C=[N+]2[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 396.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sangshetti JN, Khan FA, Shinde DB. Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36. Review. PubMed PMID: 25174923. 2: Yu L, Zhou W, Wang Z. Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1541-4. doi: 10.1016/j.bmcl.2010.12.097. Epub 2010 Dec 24. PubMed PMID: 21288715. 3: Wang Z, Zhou W. Synthesis and in vitro antibacterial activity of (2S)-N-(substitutedphenyl)-1-[(2R)-2-[(formylhydroxyamino)methyl]-1-oxohexyl]-2-p yrrolidinecarboxamides as potential peptide deformylase inhibitors. Chem Biol Drug Des. 2009 Jan;73(1):142-6. doi: 10.1111/j.1747-0285.2008.00753.x. PubMed PMID: 19152643. 4: Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925. 5: Wang W, White R, Yuan Z. Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus. Antimicrob Agents Chemother. 2006 May;50(5):1656-63. PubMed PMID: 16641432; PubMed Central PMCID: PMC1472206. 6: Butler MS, Buss AD. Natural products--the future scaffolds for novel antibiotics? Biochem Pharmacol. 2006 Mar 30;71(7):919-29. Epub 2005 Nov 14. Review. PubMed PMID: 16289393. 7: Waites KB, Reddy NB, Crabb DM, Duffy LB. Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2005 Jun;49(6):2541-2. PubMed PMID: 15917568; PubMed Central PMCID: PMC1140545. 8: Molecule of the month. LBM-415. Drug News Perspect. 2005 Jan-Feb;18(1):46. PubMed PMID: 15753974.