SC 919 is an orally bioavailable, highly selective inhibitor of all three human IP6K isoforms, exhibiting IC₅₀ values of <5.2 nM (IP6K1), <3.8 nM (IP6K2) and 0.65 nM (IP6K3). In vivo dosing in rats led to dose-dependent reductions in cellular 5 InsP₇ levels across liver, muscle, and kidney, with minimal changes in InsP₆. Functionally, SC 919 suppresses XPR1 mediated phosphate export (via the SPX domain) in HEK293 c. Chronic oral administration (single or multiple doses) in rodents and nonhuman primates significantly lowered plasma phosphate, without affecting gut uptake or renal reabsorption, and also normalized phosphate in hyperphosphataemic rat models. Additionally, SC 919 increased intracellular ATP levels in an XPR1 dependent manner in vitro, and in CKD rats it not only improved hyperphosphataemia but also restored renal ATP, reduced GDF15/FGF23/PTH, improved food intake and body weight, decreased creatinine, fibrosis, and vascular calcification
MedKoo Cat#: 466189
Name: SC-919
CAS#: 2245949-62-4
Chemical Formula: C19H16Cl2N2O4
Exact Mass: 406.0487
Molecular Weight: 407.25
Elemental Analysis: C, 56.04; H, 3.96; Cl, 17.41; N, 6.88; O, 15.71
The following data is based on the product molecular weight 407.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
