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MedKoo Cat#: 573928 | Name: Adomeglivant, (+)-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adomeglivant, (+)-, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes.

Chemical Structure

Adomeglivant, (+)-
Adomeglivant, (+)-
CAS#872260-19-0 (R-isomer)

Theoretical Analysis

MedKoo Cat#: 573928

Name: Adomeglivant, (+)-

CAS#: 872260-19-0 (R-isomer)

Chemical Formula: C32H36F3NO4

Exact Mass: 555.2596

Molecular Weight: 555.64

Elemental Analysis: C, 69.17; H, 6.53; F, 10.26; N, 2.52; O, 11.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
872260-47-4 (racemic) 1488363-78-5 (S-isomer) 872260-19-0 (R-isomer)
Synonym
(+)- Adomeglivant; Adomeglivant, (+)-
IUPAC/Chemical Name
beta-Alanine, N-(4-((1R)-1-((4'-(1,1-dimethylethyl)-2,6-dimethyl(1,1'-biphenyl)-4-yl)oxy)-4,4,4-trifluorobutyl)benzoyl)-
InChi Key
FASLTMSUPQDLIB-HHHXNRCGSA-N
InChi Code
1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3,4)5)40-27(14-16-32(33,34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13,18-19,27H,14-17H2,1-5H3,(H,36,39)(H,37,38)/t27-/m1/s1
SMILES Code
Cc1cc(O[C@H](CCC(F)(F)F)c2ccc(cc2)C(=O)NCCC(=O)O)cc(C)c1c3ccc(cc3)C(C)(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 555.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Y, Ye Z, Bellman TM, Chi T, Dai M. Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org Lett. 2015 May 1;17(9):2186-9. doi: 10.1021/acs.orglett.5b00782. Epub 2015 Apr 17. PubMed PMID: 25885795. 2: Kelly RP, Garhyan P, Raddad E, Fu H, Lim CN, Prince MJ, Pinaire JA, Loh MT, Deeg MA. Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Diabetes Obes Metab. 2015 Apr;17(4):414-22. doi: 10.1111/dom.12446. Epub 2015 Mar 2. PubMed PMID: 25656305. 3: Grover S, Dhanjal JK, Goyal S, Grover A, Sundar D. Computational identification of novel natural inhibitors of glucagon receptor for checking type II diabetes mellitus. BMC Bioinformatics. 2014;15 Suppl 16:S13. doi: 10.1186/1471-2105-15-S16-S13. Epub 2014 Dec 8. PubMed PMID: 25521597; PubMed Central PMCID: PMC4290642.