Synonym
JM-221, JM 221, JM221
IUPAC/Chemical Name
Platinum, amminebis(butanoato-O)dichloro(cyclohexanamine)-, (OC-6-43)-
InChi Key
XMOWMXXEICQRQH-UHFFFAOYSA-J
InChi Code
1S/C6H13N.2C4H8O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2-3-4(5)6;;;;/h6H,1-5,7H2;2*2-3H2,1H3,(H,5,6);2*1H;1H3;/q;;;;;;+4/p-4
SMILES Code
[O-]C(CCC)=O.[O-]C(=O)CCC.C1CCCC(C1)N.[ClH-].N.[ClH-].[Pt+4]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
556.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.
2: McKeage MJ, Abel G, Kelland LR, Harrap KR. Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro. Br J Cancer. 1994 Jan;69(1):1-7. PubMed PMID: 8286188; PubMed Central PMCID: PMC1968778.
3: Mellish KJ, Kelland LR, Harrap KR. In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin. Br J Cancer. 1993 Aug;68(2):240-50. PubMed PMID: 8347478; PubMed Central PMCID: PMC1968570.
4: Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.
