GSK366 | CAS# 1953157-39-5 | KMO Inhibitor

MedKoo Cat#: 558756 | Name: GSK366

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK366 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).

Chemical Structure

GSK366

CAS#1953157-39-5

Theoretical Analysis

MedKoo Cat#: 558756

Name: GSK366

CAS#: 1953157-39-5

Chemical Formula: C17H16ClN3O4

Exact Mass: 361.0829

Molecular Weight: 361.78

Elemental Analysis: C, 56.44; H, 4.46; Cl, 9.80; N, 11.62; O, 17.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK-366; GSK 366; GSK366

IUPAC/Chemical Name

(R)-3-(5-Chloro-6-(1-(6-methylpyridazin-3-yl)ethoxy)benzo[d]isoxazol-3-yl)propanoic acid

InChi Key

YWASLAPMFGBZQP-SNVBAGLBSA-N

InChi Code

InChI=1S/C17H16ClN3O4/c1-9-3-4-13(20-19-9)10(2)24-16-8-15-11(7-12(16)18)14(21-25-15)5-6-17(22)23/h3-4,7-8,10H,5-6H2,1-2H3,(H,22,23)/t10-/m1/s1

SMILES Code

O=C(O)CCC1=NOC2=CC(O[C@@H](C3=NN=C(C)C=C3)C)=C(Cl)C=C12

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 361.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ, Uings I, Walker AL, Webster SP, Mowat CG, Chung CW. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. doi: 10.1038/ncomms15827. PubMed PMID: 28604669; PubMed Central PMCID: PMC5477544.