IUPAC/Chemical Name
7-[1-(2-Fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline
InChi Key
VJIMKNSHIOSWQZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H12FN5/c1-11-16(13-7-6-12-4-2-8-19-14(12)10-13)21-22-23(11)15-5-3-9-20-17(15)18/h2-10H,1H3
SMILES Code
CC1=C(C2=CC=C3C=CC=NC3=C2)N=NN1C4=CC=CN=C4F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
305.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Leung K. 6-[1-(2-[18F]Fluoro-3-pyridyl)-5-methyl-1H-1,2,3-t
riazol-4-yl]quinoline. 2012 Nov 11 [updated 2013 Mar 7]. In: Molecular Imaging
and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center
for Biotechnology Information (US); 2004–2013. PMID: 23487870.
2: Kim GR, Yang JY, Hwang KS, Kim SS, Chae JS, Kan H, Ahn JH, Lee WM, Ahn SH,
Lee YM, Bae MA, Shin DS. Anti-inflammatory effect of a novel synthetic compound
1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish
model. Fish Shellfish Immunol. 2019 Apr;87:395-400. doi:
10.1016/j.fsi.2019.01.030. Epub 2019 Jan 25. PMID: 30685466.
3: Fujinaga M, Yamasaki T, Kawamura K, Kumata K, Hatori A, Yui J, Yanamoto K,
Yoshida Y, Ogawa M, Nengaki N, Maeda J, Fukumura T, Zhang MR. Synthesis and
evaluation of
6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for
positron emission tomography imaging of the metabotropic glutamate receptor type
1 in brain. Bioorg Med Chem. 2011 Jan 1;19(1):102-10. doi:
10.1016/j.bmc.2010.11.048. Epub 2010 Nov 25. PMID: 21172734.
