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MedKoo Cat#: 555608 | Name: JHU-58

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.

Chemical Structure

JHU-58
JHU-58
CAS#1632140-61-4 (free base)

Theoretical Analysis

MedKoo Cat#: 555608

Name: JHU-58

CAS#: 1632140-61-4 (free base)

Chemical Formula: C19H24N6O2

Exact Mass: 368.1961

Molecular Weight: 368.44

Elemental Analysis: C, 61.94; H, 6.57; N, 22.81; O, 8.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1632140-61-4 (free base) 1632140-59-0 (SS isomer) 1632140-62 (TFA)
Synonym
JHU-58; JHU 58; JHU58;
IUPAC/Chemical Name
(R)-2-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-3-(4-guanidinophenyl)propanamide
InChi Key
JGVSHHWPQVGYRT-CVEARBPZSA-N
InChi Code
InChI=1S/C19H24N6O2/c20-15(10-13-6-8-14(9-7-13)24-19(22)23)18(27)25-16(17(21)26)11-12-4-2-1-3-5-12/h1-9,15-16H,10-11,20H2,(H2,21,26)(H,25,27)(H4,22,23,24)/t15-,16+/m1/s1
SMILES Code
N=C(N)NC1=CC=C(C[C@@H](N)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Z, He SQ, Tseng PY, Xu Q, Tiwari V, Yang F, Shu B, Zhang T, Tang Z, Raja SN, Wang Y, Dong X, Guan Y. The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. Neuroscience. 2015 Aug 6;300:393-403. doi: 10.1016/j.neuroscience.2015.05.043. Epub 2015 May 27. PubMed PMID: 26022362; PubMed Central PMCID: PMC4485588. 2: Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 2014 Aug;155(8):1613-21. doi: 10.1016/j.pain.2014.05.008. Epub 2014 May 9. PubMed PMID: 24813294; PubMed Central PMCID: PMC4104261. 3: He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain. 2014 Mar;155(3):534-44. doi: 10.1016/j.pain.2013.12.008. Epub 2013 Dec 11. PubMed PMID: 24333779; PubMed Central PMCID: PMC3945061.