MedKoo Cat#: 584626 | Name: UoS 12258
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UoS 12258 is a positive allosteric modulator of AMPA receptors.

Chemical Structure

UoS 12258
UoS 12258
CAS#875927-64-3

Theoretical Analysis

MedKoo Cat#: 584626

Name: UoS 12258

CAS#: 875927-64-3

Chemical Formula: C17H19FN2O2S

Exact Mass: 334.1151

Molecular Weight: 334.41

Elemental Analysis: C, 61.06; H, 5.73; F, 5.68; N, 8.38; O, 9.57; S, 9.59

Price and Availability

Size Price Availability Quantity
10mg USD 370.00
50mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
UoS 12258; UoS12258; UoS-12258
IUPAC/Chemical Name
N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
InChi Key
QXQSUBKWSHMXDP-INIZCTEOSA-N
InChi Code
InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1
SMILES Code
CC(S(=O)(N[C@H]1CC2=C(C=C(C3=CC=C(F)N=C3)C=C2)C1)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID: 20614889 Ward et al (2017) Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br.J.Pharmacol. 174 370 PMID: 28009436