MedKoo Cat#: 573885 | Name: Aminolevulinic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aminolevulinic acid is a compound produced from succinyl-CoA and Glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for Actinic Keratosis

Chemical Structure

Aminolevulinic acid
Aminolevulinic acid
CAS#106-60-5 (free)

Theoretical Analysis

MedKoo Cat#: 573885

Name: Aminolevulinic acid

CAS#: 106-60-5 (free)

Chemical Formula: C5H9NO3

Exact Mass: 131.0582

Molecular Weight: 131.13

Elemental Analysis: C, 45.80; H, 6.92; N, 10.68; O, 36.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Synonym
5-ALA, 5-Aminolevulinic acid, Ameluz, Aminolevulinic acid, BF-200 ALA
IUPAC/Chemical Name
5-Amino-4-oxovaleric acid
InChi Key
ZGXJTSGNIOSYLO-UHFFFAOYSA-N
InChi Code
1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
SMILES Code
NCC(CCC(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 131.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Inoue K. 5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer. Int J Urol. 2017 Feb;24(2):97-101. doi: 10.1111/iju.13291. Review. PubMed PMID: 28191719. 2: Kumar N, Warren CB. Photodynamic Therapy for Dermatologic Conditions in the Pediatric Population: A Literature Review. Photodermatol Photoimmunol Photomed. 2017 Jan 28. doi: 10.1111/phpp.12296. [Epub ahead of print] Review. PubMed PMID: 28130791. 3: Huang Z, Shi S, Qiu H, Li D, Zou J, Hu S. Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence. Neurophotonics. 2017 Jan;4(1):011011. doi: 10.1117/1.NPh.4.1.011011. Review. PubMed PMID: 28097209; PubMed Central PMCID: PMC5227178. 4: Zhang Y, Avalos JL. Traditional and novel tools to probe the mitochondrial metabolism in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2017 Jan 9. doi: 10.1002/wsbm.1373. [Epub ahead of print] Review. PubMed PMID: 28067471. 5: Lane AM, McKay JT, Bonkovsky HL. Advances in the management of erythropoietic protoporphyria - role of afamelanotide. Appl Clin Genet. 2016 Dec 12;9:179-189. doi: 10.2147/TACG.S122030. Review. PubMed PMID: 28003770; PubMed Central PMCID: PMC5161401. 6: Ameluz for actinic keratoses. Med Lett Drugs Ther. 2016 Dec 5;58(1509):155-156. Review. PubMed PMID: 27906150. 7: Xue J, Liu C, Liu Y. Photodynamic therapy as an alternative treatment for relapsed or refractory mycosis fungoides: a systemic review. Photodiagnosis Photodyn Ther. 2016 Nov 22. pii: S1572-1000(16)30184-3. doi: 10.1016/j.pdpdt.2016.11.010. [Epub ahead of print] Review. PubMed PMID: 27888162. 8: Senders JT, Muskens IS, Schnoor R, Karhade AV, Cote DJ, Smith TR, Broekman ML. Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results. Acta Neurochir (Wien). 2017 Jan;159(1):151-167. doi: 10.1007/s00701-016-3028-5. Review. PubMed PMID: 27878374; PubMed Central PMCID: PMC5177668. 9: Belykh E, Martirosyan NL, Yagmurlu K, Miller EJ, Eschbacher JM, Izadyyazdanabadi M, Bardonova LA, Byvaltsev VA, Nakaji P, Preul MC. Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions. Front Surg. 2016 Oct 17;3:55. Review. PubMed PMID: 27800481; PubMed Central PMCID: PMC5066076. 10: Arora S, Young S, Kodali S, Singal AK. Hepatic porphyria: A narrative review. Indian J Gastroenterol. 2016 Nov;35(6):405-418. Review. PubMed PMID: 27796941. 11: Cohen DK, Lee PK. Photodynamic Therapy for Non-Melanoma Skin Cancers. Cancers (Basel). 2016 Oct 4;8(10). pii: E90. Review. PubMed PMID: 27782043; PubMed Central PMCID: PMC5082380. 12: Chou R, Selph S, Buckley DI, Fu R, Griffin JC, Grusing S, Gore JL. Comparative Effectiveness of Fluorescent Versus White Light Cystoscopy for Initial Diagnosis or Surveillance of Bladder Cancer on Clinical Outcomes: Systematic Review and Meta-Analysis. J Urol. 2016 Oct 22. pii: S0022-5347(16)31585-3. doi: 10.1016/j.juro.2016.10.061. [Epub ahead of print] Review. PubMed PMID: 27780784. 13: Girotti AW, Fahey JM, Korytowski W. Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy. Curr Med Chem. 2016;23(24):2754-2769. Review. PubMed PMID: 27776475. 14: Fonda-Pascual P, Moreno-Arrones OM, Alegre-Sanchez A, Saceda-Corralo D, Buendia-Castaño D, Pindado-Ortega C, Fernandez-Gonzalez P, Velazquez-Kennedy K, Calvo-Sánchez MI, Harto-Castaño A, Perez-Garcia B, Bagazgoitia L, Vaño-Galvan S, Espada J, Jaen-Olasolo P. In situ production of ROS in the skin by photodynamic therapy as a powerful tool in clinical dermatology. Methods. 2016 Oct 15;109:190-202. doi: 10.1016/j.ymeth.2016.07.008. Review. PubMed PMID: 27422482. 15: Halani SH, Adamson DC. Clinical utility of 5-aminolevulinic acid HCl to better visualize and more completely remove gliomas. Onco Targets Ther. 2016 Sep 12;9:5629-42. doi: 10.2147/OTT.S97030. Review. PubMed PMID: 27672334; PubMed Central PMCID: PMC5026178. 16: Barbaric J, Abbott R, Posadzki P, Car M, Gunn LH, Layton AM, Majeed A, Car J. Light therapies for acne. Cochrane Database Syst Rev. 2016 Sep 27;9:CD007917. [Epub ahead of print] Review. PubMed PMID: 27670126. 17: Andrew H, Gossedge G, Croft J, Corrigan N, Brown JM, West N, Quirke P, Tolan D, Cahill R, Jayne DG. Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery (GLiSten): a multicentre, multinational feasibility study of fluorescence in predicting lymph node-positive disease. Southampton (UK): NIHR Journals Library; 2016 Aug. PubMed PMID: 27536753. 18: Maranda EL, Nguyen AH, Lim VM, Shah VV, Jimenez JJ. Erythroplasia of Queyrat treated by laser and light modalities: a systematic review. Lasers Med Sci. 2016 Dec;31(9):1971-1976. Review. PubMed PMID: 27324019. 19: Fujita AK, Rodrigues PG, Requena MB, Escobar A, da Rocha RW, Nardi AB, Kurachi C, de Menezes PF, Bagnato VS. Fluorescence evaluations for porphyrin formation during topical PDT using ALA and methyl-ALA mixtures in pig skin models. Photodiagnosis Photodyn Ther. 2016 Sep;15:236-44. doi: 10.1016/j.pdpdt.2016.05.008. Review. PubMed PMID: 27288253. 20: Kamp MA, Krause Molle Z, Munoz-Bendix C, Rapp M, Sabel M, Steiger HJ, Cornelius JF. Various shades of red-a systematic analysis of qualitative estimation of ALA-derived fluorescence in neurosurgery. Neurosurg Rev. 2016 May 25. [Epub ahead of print] Review. PubMed PMID: 27225452.