BMX-010 | CAS#219818-60-7 | SOD Mimic

MedKoo Cat#: 555394 | Name: BMX010

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMX-010, also known as AEOL-10113, is Porphyrin-Based SOD Mimic. BMX-010 ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. Topically applied manganese-porphyrins BMX-010 displays a significant anti-inflammatory response in a mouse model of allergic dermatitis. BMX010 Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function.

Chemical Structure

BMX010

CAS#219818-60-7

Theoretical Analysis

MedKoo Cat#: 555394

Name: BMX010

CAS#: 219818-60-7

Chemical Formula: C48H44Cl5MnN8

Exact Mass:

Molecular Weight: 965.12

Elemental Analysis: C, 59.74; H, 4.60; Cl, 18.37; Mn, 5.69; N, 11.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BMX-010; BMX-010; BMX-010; AEOL-10113; AEOL-10113; AEOL-10113; MnTE-2-PyPCl5;

IUPAC/Chemical Name

Manganese(III)meso-tetrakis(N-ethylpyridinium-2-yl) porphyrin chloride

InChi Key

UGVOBAHBYOONQU-UHFFFAOYSA-I

InChi Code

InChI=1S/C48H44N8.5ClH.Mn/c1-5-53-29-13-9-17-41(53)45-33-21-23-35(49-33)46(42-18-10-14-30-54(42)6-2)37-25-27-39(51-37)48(44-20-12-16-32-56(44)8-4)40-28-26-38(52-40)47(36-24-22-34(45)50-36)43-19-11-15-31-55(43)7-3;;;;;;/h9-32H,5-8H2,1-4H3;5*1H;/q+2;;;;;;+3/p-5

SMILES Code

[Cl-][Mn+3]123[N]4=C(C(C5=[N+](CC)C=CC=C5)=C6C=CC([N-]63)=C7C8=[N+](CC)C=CC=C8)C=CC4=C(C9=[N+](CC)C=CC=C9)C([N-]%102)=CC=C%10C(C%11=[N+](CC)C=CC=C%11)=C%12C=CC7=[N]%121.[Cl-].[Cl-].[Cl-].[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 965.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Maia CGC, de Araujo BCR, de Freitas-Marques MB, da Costa IF, Yoshida MI, da Nova Mussel W, Sebastião RCO, Rebouças JS. Thermal Stability Kinetics and Shelf Life Estimation of the Redox-Active Therapeutic and Mimic of Superoxide Dismutase Enzyme, Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin Chloride (MnTE-2-PyPCl5, BMX-010). Oxid Med Cell Longev. 2021 Dec 6;2021:7003861. doi: 10.1155/2021/7003861. PMID: 34912497; PMCID: PMC8668311. 2: Valachová K, Rapta P, Moura NMM, Batinic-Haberle I, Šoltés L. Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins-Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions. Int J Mol Sci. 2021 Aug 10;22(16):8608. doi: 10.3390/ijms22168608. PMID: 34445313; PMCID: PMC8395334. 3: Batinic-Haberle I, Tovmasyan A, Huang Z, Duan W, Du L, Siamakpour-Reihani S, Cao Z, Sheng H, Spasojevic I, Alvarez Secord A. H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. Oxid Med Cell Longev. 2021 Mar 15;2021:6653790. doi: 10.1155/2021/6653790. PMID: 33815656; PMCID: PMC7987459. 4: Thamilarasan M, Estupinan R, Batinic-Haberle I, Zennadi R. Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso- occlusion in vivo. Blood Adv. 2020 Jun 9;4(11):2372-2386. doi: 10.1182/bloodadvances.2020001642. PMID: 32479589; PMCID: PMC7284092. 5: Barbosa AM, Sarmento-Neto JF, Menezes Filho JER, Jesus ICG, Souza DS, Vasconcelos VMN, Gomes FDL, Lara A, Araújo JSS, Mattos SS, Vasconcelos CML, Guatimosim S, Cruz JS, Batinic-Haberle I, Araújo DAM, Rebouças JS, Gomes ER. Redox-Active Drug, MnTE-2-PyP5+, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function. Oxid Med Cell Longev. 2020 Mar 21;2020:4850697. doi: 10.1155/2020/4850697. PMID: 32273944; PMCID: PMC7115175. 6: Shrishrimal S, Chatterjee A, Kosmacek EA, Davis PJ, McDonald JT, Oberley- Deegan RE. Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity. Free Radic Biol Med. 2020 May 20;152:255-270. doi: 10.1016/j.freeradbiomed.2020.03.014. Epub 2020 Mar 25. PMID: 32222469; PMCID: PMC7276298. 7: Gad SC, Sullivan DW Jr, Mujer CV, Spainhour CB, Crapo JD. Nonclinical Safety and Toxicokinetics of MnTE-2-PyP (BMX-010), a Topical Agent in Phase 2 Trials for Psoriasis and Atopic Dermatitis. Int J Toxicol. 2019 Jul/Aug;38(4):291-302. doi: 10.1177/1091581819852325. PMID: 31333066. 8: Bellot GL, Dong X, Lahiri A, Sebastin SJ, Batinic-Haberle I, Pervaiz S, Puhaindran ME. MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol. 2019 Jan;20:307-320. doi: 10.1016/j.redox.2018.10.014. Epub 2018 Oct 23. PMID: 30390545; PMCID: PMC6218638. 9: Batinic-Haberle I, Tovmasyan A, Spasojevic I. Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury. Antioxid Redox Signal. 2018 Dec 1;29(16):1691-1724. doi: 10.1089/ars.2017.7453. Epub 2018 Aug 28. PMID: 29926755; PMCID: PMC6207162. 10: Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ. BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. Am J Transplant. 2018 Aug;18(8):1879-1889. doi: 10.1111/ajt.14705. Epub 2018 Mar 31. PMID: 29464912. 11: Stover K, Fukuyama T, Young AT, Daniele MA, Oberley R, Crapo JD, Bäumer W. Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis. Arch Dermatol Res. 2016 Dec;308(10):711-721. doi: 10.1007/s00403-016-1693-0. Epub 2016 Oct 5. PMID: 27709295; PMCID: PMC7945677. 12: Archambeau JO, Tovmasyan A, Pearlstein RD, Crapo JD, Batinic-Haberle I. Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. Redox Biol. 2013 Oct 25;1(1):599-607. doi: 10.1016/j.redox.2013.10.002. PMID: 24363995; PMCID: PMC3863774. 13: Gad SC, Sullivan DW Jr, Crapo JD, Spainhour CB. A nonclinical safety assessment of MnTE-2-PyP, a manganese porphyrin. Int J Toxicol. 2013 Jul;32(4):274-87. doi: 10.1177/1091581813490203. Epub 2013 May 23. PMID: 23704100.