MedKoo Cat#: 130464 | Name: ND-478

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ND-478 is the prodrug of ND-322, which is a gelatinase inhibitor that is used to combat the damaging effects of neurological diseases caused by MMP-9. ND-322 is then further metabolized to form ND-364, which is an even more potent gelatinase inhibitor.

Chemical Structure

ND-478
ND-478
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130464

Name: ND-478

CAS#: N/A

Chemical Formula: C21H29Cl2N5O4S2

Exact Mass:

Molecular Weight: 550.51

Elemental Analysis: C, 45.82; H, 5.31; Cl, 12.88; N, 12.72; O, 11.62; S, 11.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ND-478; ND478; ND 478
IUPAC/Chemical Name
(2S)-2-amino-5-guanidino-N-(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)pentanamide dihydrochloride
InChi Key
YYZCOYMRFSFGIR-KGSYHEICSA-N
InChi Code
InChI=1S/C21H27N5O4S2.2ClH/c22-19(2-1-11-25-21(23)24)20(27)26-14-3-5-15(6-4-14)30-16-7-9-18(10-8-16)32(28,29)13-17-12-31-17;;/h3-10,17,19H,1-2,11-13,22H2,(H,26,27)(H4,23,24,25);2*1H/t17?,19-;;/m0../s1
SMILES Code
NC(NCCC[C@@H](C(NC1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(CC3SC3)=O)=O)N)=N.Cl.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 550.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Song W, Peng Z, Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Lee M, Ikejiri M, Cui J, Gu Z, Chang M. Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier. ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73. doi: 10.1021/cn400077d. Epub 2013 May 30. PMID: 23687970; PMCID: PMC3750675. 2. Gooyit M, Lee M, Schroeder VA, Ikejiri M, Suckow MA, Mobashery S, Chang M. Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem. 2011 Oct 13;54(19):6676-90. doi: 10.1021/jm200566e. Epub 2011 Sep 6. PMID: 21866961; PMCID: PMC3190643.