MedKoo Cat#: 573884 | Name: (R)-Aminoglutethimide tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-Aminoglutethimide tartrate is an anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.

Chemical Structure

(R)-Aminoglutethimide tartrate
(R)-Aminoglutethimide tartrate
CAS#57344-88-4 (R isomer tartrate)

Theoretical Analysis

MedKoo Cat#: 573884

Name: (R)-Aminoglutethimide tartrate

CAS#: 57344-88-4 (R isomer tartrate)

Chemical Formula: C17H22N2O8

Exact Mass: 382.1376

Molecular Weight: 382.37

Elemental Analysis: C, 53.40; H, 5.80; N, 7.33; O, 33.47

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Synonym
(R)-Aminoglutethimide tartrate, D-Aminoglutethimide tartrate
IUPAC/Chemical Name
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, (R)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
InChi Key
DQUXPVVSVXIQNE-IMXLTCNTSA-N
InChi Code
1S/C13H16N2O2.C4H6O6/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9;5-1(3(7)8)2(6)4(9)10/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t13-;1-,2-/m11/s1
SMILES Code
CC[C@@]1(CCC(=O)NC1=O)c2ccc(cc2)N.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
   1: Mutsuga M, Asaoka Y, Imura N, Miyoshi T, Togashi Y. Aminoglutethimide-induced lysosomal changes in adrenal gland in mice. Exp Toxicol Pathol. 2017 Sep 5;69(7):424-429. doi: 10.1016/j.etp.2017.04.004. Epub 2017 Apr 11. PubMed PMID: 28410883. 2: Ng W, Metushi IG, Uetrecht J. Hepatic effects of aminoglutethimide: a model aromatic amine. J Immunotoxicol. 2015 Jan-Mar;12(1):24-32. doi: 10.3109/1547691X.2013.867912. Epub 2013 Dec 19. PubMed PMID: 24350727. 3: Lønning PE, Kvinnsland S. Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer. Drugs. 1988 Jun;35(6):685-710. Review. PubMed PMID: 3048976. 4: Santen RJ, Misbin RI. Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981 Sep-Oct;1(2):95-120. Review. PubMed PMID: 6765487. 5: Hughss SW, Burley DM. Aminoglutethimide: a "side-effect" turned to therapeutic advantage. Postgrad Med J. 1970 Jul;46(537):409-16. Review. PubMed PMID: 4920933; PubMed Central PMCID: PMC2467063.