MedKoo Cat#: 592613 | Name: Aminoglutethimide phosphate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aminoglutethimide phosphate is a P-450 inhibitor. Australia requires an import license for this product.

Chemical Structure

Aminoglutethimide phosphate
Aminoglutethimide phosphate
CAS#23734-88-5 (phosphate)

Theoretical Analysis

MedKoo Cat#: 592613

Name: Aminoglutethimide phosphate

CAS#: 23734-88-5 (phosphate)

Chemical Formula: C13H19N2O6P

Exact Mass: 330.0981

Molecular Weight: 330.28

Elemental Analysis: C, 47.28; H, 5.80; N, 8.48; O, 29.06; P, 9.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Aminoglutethimide phosphate
IUPAC/Chemical Name
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, phosphate (1:1) (8CI)
InChi Key
TXHYGJUNRXVGNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16N2O2.H3O4P/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9;1-5(2,3)4/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);(H3,1,2,3,4)
SMILES Code
O=C(C(CC)(C1=CC=C(N)C=C1)CC2)NC2=O.O=P(O)(O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mohanty N, Chainy GB. Follicular growth rate and lack of influence of oestradiol valerate, testosterone propionate and aminoglutethimide phosphate on ovarian follicular development in the musk shrew, Suncus murinus L. Indian J Exp Biol. 1993 Nov;31(11):869-73. PubMed PMID: 8112760. 2: Fuller GB, Markaverich BM, Hobson W. Effect of aminoglutethimide phosphate on in vitro oestradiol stimulated progesterone synthesis by rabbit corpora lutea. Acta Endocrinol (Copenh). 1978 Jan;87(1):164-72. PubMed PMID: 579531. 3: Limanowski A, Miśkowiak B. [Effect of aminoglutethimide phosphate on the testes and seminal vesicles in rats]. Endokrynol Pol. 1972 May-Jun;23(3):231-45. Russian. PubMed PMID: 5069701. 4: Khalil MW, Morley P, Glasier MA, Armstrong DT, Lang T. Formation of 4-oestrene-3,17-dione (19-norandrostenedione) by porcine granulosa cells in vitro is inhibited by the aromatase inhibitor 4-hydroxyandrostenedione and the cytochrome P-450 inhibitors aminoglutethimide phosphate and ketoconazole. J Endocrinol. 1989 Feb;120(2):251-60. PubMed PMID: 2926299. 5: Torres CA, First NL. Gestation length in rabbits-effect of aminoglutethimide phosphate, dexamethasone, pregnenolone and progesterone. J Anim Sci. 1976 Jan;42(1):131-7. PubMed PMID: 1248961. 6: Glasser SR, Northcutt RC, Chytil F, Strott CA. The influence of an anti-steroidogenic drug (aminoglutethimide phosphate) on pregnancy maintenance. Endocrinology. 1972 May;90(5):1363-70. PubMed PMID: 5012747. 7: Ying SY, Greep RO. Prevention of aminoglutethimide phosphate (AGP) block of ovulation in PMS-treated immature rats. Proc Soc Exp Biol Med. 1971 Mar;136(3):916-9. PubMed PMID: 4929200. 8: Miśkowiak B. [Pattern of hypothalamo-pituitary neurosecretion in the rat following injection of a single dose of aminoglutethimide phosphate]. Endokrynol Pol. 1972 May-Jun;23(3):221-9. Polish. PubMed PMID: 5069700. 9: Berhman HR, Armstrong DT, Greep RO. Studies on the rapid cholesterol-depleting and steroidogenic actions of luteinizing hormone in the rat ovary: effects of aminoglutethimide phosphate. Can J Biochem. 1970 Aug;48(8):881-4. PubMed PMID: 5452725. 10: Armstrong DT, Dorrington JH, Robinson J. Effects of indomethacin and aminoglutethimide phosphate in vivo on luteinizing-hormone-induced alterations of cyclic adenosine monophosphate, prostaglandin F, and steroid levels in preovulatory rat ovaries. Can J Biochem. 1976 Sep;54(9):796-802. PubMed PMID: 183880. 11: Weniger JP, Vaultier JP, Coumaros G, Zeis A. [Aminoglutethimide, an inhibitor of aromatase from chick embryo ovary]. C R Acad Sci III. 1985;301(2):37-40. French. PubMed PMID: 2931162. 12: Leung P, Gidari AS. Effect of aminoglutethimide on murine fetal hepatic erythroid colony formation. Experientia. 1985 Apr 15;41(4):498-500. PubMed PMID: 3987874. 13: Malendowicz LK. Comparative studies on the effects of aminoglutethimide on hamster and rat adrenal cortex. Exp Toxicol Pathol. 1992 Apr;44(2):81-5. PubMed PMID: 1617291. 14: Falke HE, Degenhart HJ, Abeln GJ, Visser HK. Effects of 25-hydroxycholesterol and aminoglutethimide in isolated rat adrenal cells. A model for congenital lipoid adrenal hyperplasia? Mol Cell Endocrinol. 1976 Jan;4(2):107-14. PubMed PMID: 174962. 15: Albrecht E. Prevention of cystic ovary induction in rabbits by aminoglutethimide. Acta Endocrinol (Copenh). 1980 Jun;94(2):242-5. PubMed PMID: 6932152. 16: Johnson PA, Johnson AL, van Tienhoven A. Evidence for a positive feedback interaction between progesterone and luteinizing hormone in the induction of ovulation in the hen, Gallus domesticus. Gen Comp Endocrinol. 1985 Jun;58(3):478-85. PubMed PMID: 4007483. 17: Rabe T, Rabe D, Weidenhammer K, Runnebaum B. Inhibition of human placental progesterone synthesis by aminoglutethimide in vitro. Int J Biol Res Pregnancy. 1982;3(4):167-72. PubMed PMID: 6961114. 18: Evans CA, Kennedy TG. Blastocyst implantation in ovariectomized, adrenalectomized hamsters treated with inhibitors of steroidogenesis during the pre-implantation period. Steroids. 1980 Jul;36(1):41-52. PubMed PMID: 6447931. 19: Yoshimura Y, Hosoi Y, Atlas SJ, Bongiovanni AM, Santulli R, Wallach EE. The effect of ovarian steroidogenesis on ovulation and fertilizability in the in vitro perfused rabbit ovary. Biol Reprod. 1986 Nov;35(4):943-8. PubMed PMID: 3643801. 20: Khalil MW, Strutt B, Vachon D, Killinger DW. Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells. J Steroid Biochem Mol Biol. 1994 Apr;48(5-6):545-52. PubMed PMID: 8180117.