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MedKoo Cat#: 585077 | Name: Thiocolchicoside
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiocolchicoside is used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography.

Chemical Structure

Thiocolchicoside
Thiocolchicoside
CAS#602-41-5

Theoretical Analysis

MedKoo Cat#: 585077

Name: Thiocolchicoside

CAS#: 602-41-5

Chemical Formula: C27H33NO10S

Exact Mass: 563.1825

Molecular Weight: 563.62

Elemental Analysis: C, 57.54; H, 5.90; N, 2.49; O, 28.39; S, 5.69

Price and Availability

Size Price Availability Quantity
20mg USD 420.00
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Related CAS #
No Data
Synonym
Thiocolchicoside; R. 271; Coltramyl
IUPAC/Chemical Name
2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine
InChi Key
LEQAKWQJCITZNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)
SMILES Code
COC1=C2C3=CC=C(C(C=C3C(CCC2=CC(OC4OC(C(C(O)C4O)O)CO)=C1OC)NC(C)=O)=O)SC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 563.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bianconi A, Fiore M, Rosso A, Acuti Martellucci C, Calò GL, Cioni G, Imperiali G, Orazi V, Tiseo M, Troia A, Zauli E. Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2024 Oct 15;13(20):6133. doi: 10.3390/jcm13206133. PMID: 39458083; PMCID: PMC11508309. 2: Devi A, Khanwelkar C. A Comparative Study of Skeletal Muscle Relaxant Effects of Thiocolchicoside, Diazepam and Their Combination in Wistar Rats Using the Rotarod Apparatus. Cureus. 2024 Sep 16;16(9):e69513. doi: 10.7759/cureus.69513. PMID: 39416571; PMCID: PMC11481424. 3: Sharma A, Singh S, Saini G, Sharma S, Singh B, Choudhary D. Quality by design-based development and in vitro evaluation of dual release tablet of etoricoxib and thiocolchicoside: A novel chronotherapeutic approach for arthritis pain management. Ann Pharm Fr. 2024 Nov;82(6):1103-1117. doi: 10.1016/j.pharma.2024.07.004. Epub 2024 Jul 11. PMID: 39002854. 4: Topal İ, Yılmaz O. Effectiveness of Mesotherapy in Post-COVID Pain Syndrome: Retrospective Cohort Study of 96 Patients. Clin Ther. 2024 Aug;46(8):e1-e5. doi: 10.1016/j.clinthera.2024.05.004. Epub 2024 Jun 22. PMID: 38910071. 5: Uner B, Baranauskaite Ortasoz J, Tas C. Development of thermosensitive liposome-containing in-situ gel systems for intranasal administration of thiocolchicoside and in vivo evaluation in a rabbit model. Pharm Dev Technol. 2024 Jul;29(6):582-595. doi: 10.1080/10837450.2024.2364707. Epub 2024 Jun 13. PMID: 38841795. 6: Scaturro D, Migliorino D, Lauricella L, Quartararo F, Calabrese N, Tomasello S, Vecchio M, Letizia Mauro G. Extracorporeal ShockWave Treatment vs. mesotherapy in the treatment of myofascial syndromes: a clinical trial. Front Med (Lausanne). 2024 May 22;11:1388922. doi: 10.3389/fmed.2024.1388922. PMID: 38841584; PMCID: PMC11152160. 7: Mustafa A, Indiran MA, Ramalingam K, Perumal E, Shanmugham R, Karobari MI. Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study. Sci Rep. 2024 Apr 23;14(1):9270. doi: 10.1038/s41598-024-60046-1. PMID: 38649421; PMCID: PMC11035588. 8: Khan BA, Naz F, Alqahtani A, Khalid Khan M. A nanocomposite competent to overcome solubility and permeation issues of capsaicin and thiocolchicoside simultaneously in gout management: Fabrication of nanocubosomes. Saudi Pharm J. 2024 May;32(5):102050. doi: 10.1016/j.jsps.2024.102050. Epub 2024 Mar 24. PMID: 38577488; PMCID: PMC10992725. 9: Alves JC, Santos A, Lafuente P. Evaluation of different substance combinations in a multiple-session mesotherapy protocol for the management of osteoarthritis in dogs: a retrospective study. J Am Vet Med Assoc. 2024 Mar 19;262(8):1-7. doi: 10.2460/javma.23.10.0588. PMID: 38503053. 10: Ozkan M, Karahan I, Yalcin S, Sengul Aycicek G. Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer. Medeni Med J. 2023 Dec 26;38(4):284-290. doi: 10.4274/MMJ.galenos.2023.03063. PMID: 38148726; PMCID: PMC10759939. 11: Mustafa A, Arumugham Indiran M, Shanmugham R, Ramalingam K. Anti- inflammatory activity of lauric acid, thiocolchicoside and thiocolchicoside- lauric acid formulation. Bioinformation. 2023 Nov 30;19(11):1075-1080. doi: 10.6026/973206300191075. PMID: 38046516; PMCID: PMC10692977. 12: Karmakar A, Arora S, Singal R, Mitra S, Gitika, Saha M, Mitra M. The Efficacy and Safety of a Combination of Thiocolchicoside and Etoricoxib in Low Back Pain (ESCoTEL): A Randomized Active-Controlled Trial. Cureus. 2023 Oct 25;15(10):e47621. doi: 10.7759/cureus.47621. PMID: 38021944; PMCID: PMC10681115. 13: M A, I MA, Ramalingam K, S R. Evaluation of the Anti-inflammatory, Antimicrobial, Antioxidant, and Cytotoxic Effects of Chitosan Thiocolchicoside- Lauric Acid Nanogel. Cureus. 2023 Sep 26;15(9):e46003. doi: 10.7759/cureus.46003. PMID: 37900405; PMCID: PMC10600588. 14: M A, I MA, Ramalingam K, S R, Perumal E. Cytocompatibility and Wound Healing Activity of Chitosan Thiocolchicoside Lauric Acid Nanogel in Human Gingival Fibroblast Cells. Cureus. 2023 Aug 18;15(8):e43727. doi: 10.7759/cureus.43727. PMID: 37727182; PMCID: PMC10505684. 15: Prajapati P, Pulusu VS, Shah S. Principles of White Analytical Chemistry and Design of Experiments to Development of Stability-Indicating Chromatographic Method for the Simultaneous Estimation of Thiocolchicoside and Lornoxicam. J AOAC Int. 2023 Nov 2;106(6):1654-1665. doi: 10.1093/jaoacint/qsad082. PMID: 37462527. 16: Mahmood A, Erum A, Tulain UR, Shafiq S, Malik NS, Sidra, Khan MT, Alqahtani MS. Aloe vera-Based Polymeric Network: A Promising Approach for Sustained Drug Delivery, Development, Characterization, and In Vitro Evaluation. Gels. 2023 Jun 8;9(6):474. doi: 10.3390/gels9060474. PMID: 37367144; PMCID: PMC10298059. 17: Iliopoulos K, Koufaki P, Tsilikas S, Avramidis K, Tsagkalis A, Mavragani C, Zintzaras E. A randomized controlled trial evaluating the short-term efficacy of a single-administration intramuscular injection with the fixed combination of thiocolchicoside-diclofenac versus diclofenac monotherapy in patients with acute moderate-to-severe low back pain. BMC Musculoskelet Disord. 2023 Jun 10;24(1):476. doi: 10.1186/s12891-023-06599-0. PMID: 37301824; PMCID: PMC10257820. 18: Thakur N, Goswami M, Deka Dey A, Kaur B, Sharma C, Kumar A. Fabrication and Synthesis of Thiococlchicoside Loaded Matrix Type Transdermal Patch. Pharm Nanotechnol. 2024;12(2):143-154. doi: 10.2174/2211738511666230606120828. PMID: 37282636. 19: Prajapati P, Pulusu VS, Shah S. Red, Green, and Blue Model-Based Assessment and Principles of White Analytical Chemistry to Robust Stability-Indicating Chromatographic Estimation of Thiocolchicoside and Diclofenac Sodium. J AOAC Int. 2023 Sep 1;106(5):1374-1388. doi: 10.1093/jaoacint/qsad052. PMID: 37137235. 20: Scaturro D, Vitagliani F, Signa G, Tomasello S, Tumminelli LG, Picelli A, Smania N, Letizia Mauro G. Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy. Biomedicines. 2023 Mar 14;11(3):892. doi: 10.3390/biomedicines11030892. PMID: 36979871; PMCID: PMC10045341.