Synonym
Clorexolone; Flonatril; Klorex; Nefrolan; RP 12833; RP-12833; RP12833;
IUPAC/Chemical Name
6-chloro-2-cyclohexyl-3-oxoisoindoline-5-sulfonamide
InChi Key
VPMWFZKOWULPGT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H17ClN2O3S/c15-12-6-9-8-17(10-4-2-1-3-5-10)14(18)11(9)7-13(12)21(16,19)20/h6-7,10H,1-5,8H2,(H2,16,19,20)
SMILES Code
O=S(C1=CC2=C(CN(C3CCCCC3)C2=O)C=C1Cl)(N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: BLOOMFIELD SS, TETREAULT L. A PHARMACOLOGY TEACHING EXERCISE IN DRUG EVALUATION: A COMPARISON OF THE DIURETIC EFFICACY OF CLOREXOLONE, HYDROCHLOROTHIAZIDE AND A PLACEBO IN NORMAL SUBJECTS. Can Med Assoc J. 1965 Mar 27;92:662-5. PubMed PMID: 14269436; PubMed Central PMCID: PMC1928249.
2: MAXWELL DR, MCLUSKY JM. HYPOTENSIVE ACTION OF HYDROCHLOROTHIAZIDE AND CLOREXOLONE IN THE CONSCIOUS NORMOTENSIVE DOG. Nature. 1964 Apr 18;202:300-1. PubMed PMID: 14167796.
3: Mary P, Mirouze J. [Clinical trial of the salidiuretic clorexolone 12.833 R.P. (Flonatril)]. Sem Ther. 1966 Nov;42(9):529-32. French. PubMed PMID: 5988528.
4: Hicks BH, Ward JD, Jarrett RJ, Keen H, Wise P. A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics. Metabolism. 1973 Feb;22(2):101-9. PubMed PMID: 4567002.
5: Russell RP, Macaraeg PV Jr, Schrogie JJ. Comparison of clorexolone, a new diuretic, with hydrochlorothiazide. Clin Pharmacol Ther. 1969 Mar-Apr;10(2):265-71. PubMed PMID: 4887299.
6: Gartha IV. Clorexolone: a new oral diuretic. Appl Ther. 1967 Dec;9(12):998-1001. PubMed PMID: 4865373.
7: Corbett K, Edwards SA, Lee GE, Threlfall TL. Metabolism of 5-chloro-2-cyclohexyl-1-oxo-6-sulphamoyl isoindoline, clorexolone (M and B 8430). Nature. 1965 Oct 16;208(5007):286-7. PubMed PMID: 5882456.
8: van der Merwe CJ, Kruger SA. The antihypertensive effect of guanfacine compared with methyldopa. S Afr Med J. 1980 Mar 15;57(11):400-4. PubMed PMID: 6105713.
9: Baba WI, Lant AF, Wilson GM. Studies on the mechanism and characteristics of action of a new phthalimidine diuretic, clorexolone. Clin Pharmacol Ther. 1966 Mar-Apr;7(2):212-23. PubMed PMID: 5934251.
10: Lant AF, Baba WI, Wilson GM. On the clinical evaluation of diuretics with particular reference to a new phthalimidine diuretic, clorexolone. Clin Pharmacol Ther. 1966 Mar-Apr;7(2):196-211. PubMed PMID: 5934250.
11: Mars G, Nebuloni G, Regoli U. [Biochemico-clinical studies on the activity of a new oral diuretic (clorexolone) in persons of advanced age]. G Gerontol. 1968 Mar;16(3):231-41. Italian. PubMed PMID: 5715956.
12: Verbov JL, Tunstall-Pedoe DS, Cooke TJ. A comparative study with clorexolone: an oral hypotensive and diuretic. Br J Clin Pract. 1966 Jul;20(7):351-60. PubMed PMID: 5940967.
13: Cornish EJ, Lee GE, Wragg WR. The diuretic activity of clorexolone and some related phthalimides and 1-oxoisoindolines. J Pharm Pharmacol. 1966 Feb;18(2):65-80. PubMed PMID: 4380757.
14: MacNeil S, Jennings G, Eastwood PR, Paschalis C, Jenner FA. Lithium and the antidiuretic hormone. Br J Clin Pharmacol. 1976 Apr;3(2):305-13. PubMed PMID: 788747; PubMed Central PMCID: PMC1428883.
15: TETREAULT L, BLOOMFIELD S. [A PEDAGOGIC EXPERIMENT IN PHARMACOLOGY. EVALUATION IN MEDICAL STUDENTS OF THE DIURETIC EFFECTS OF CHLOREXOLONE, HYDROCHLOROTHIAZIDE AND PLACEBO]. Union Med Can. 1965 Feb;94:171-5. French. PubMed PMID: 14303160.
16: Bayeli PF, Montagnani M, Zampetti LP, Antonelli A. [Experimental study in humans of diuresis produced by chlorexolone (5-chloro-2-cyclohexyl-l-oxo-6-sulfanoylisoindoline)]. Boll Soc Ital Biol Sper. 1969 Apr 15;45(7):406-10. Italian. PubMed PMID: 5355875.
