LG 6-102 | CAS#132798-30-2 | antiarrhythmic agent

MedKoo Cat#: 598779 | Name: LG 6-102

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG 6-102 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.

Chemical Structure

LG 6-102

CAS#132798-30-2

Theoretical Analysis

MedKoo Cat#: 598779

Name: LG 6-102

CAS#: 132798-30-2

Chemical Formula: C22H30ClNO3

Exact Mass:

Molecular Weight: 391.94

Elemental Analysis: C, 67.42; H, 7.72; Cl, 9.04; N, 3.57; O, 12.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LG 6-102; LG-6-102; LG6-102;

IUPAC/Chemical Name

1-(2-(2-methoxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride

InChi Key

WDWSTEIFIUFHBD-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H29NO3.ClH/c1-3-15-23-16-19(25-2)17-26-22-12-8-7-11-20(22)21(24)14-13-18-9-5-4-6-10-18;/h4-12,19,23H,3,13-17H2,1-2H3;1H

SMILES Code

O=C(C1=CC=CC=C1OCC(OC)CNCCC)CCC2=CC=CC=C2.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LG 6-102 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.

In vitro activity:

TBD

In vivo activity:

Rats were treated with LG 6-101 (16, 32, 64, 128, 256 mg kg-1 bodyweight), LG 6-102 (4, 8, 16, 32, 64 mg kg-1 bodyweight) and propafenone (32, 64, 128, 256 mg kg-1 bodyweight) by gavage twice daily during 4 days. Both, LG 6-101 and LG 6-102 showed strong antiarrhythmic effects against arrhythmias induced on the fifth day by infusion of aconitine (10 micrograms kg-1 min-1). LG 6-102 was significantly more effective against cardiac arrest caused by infusion of aconitine (P less than or equal to 0.05) than LG 6-101. Reference: Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. https://pubmed.ncbi.nlm.nih.gov/1620247/

Preparing Stock Solutions

The following data is based on the product molecular weight 391.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Wascher TC, Dittrich P, Kukovetz WR. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. doi: 10.1007/BF00176627. PMID: 1620247. 2. Wascher TC, Dittrich P, Kukovetz WR. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. PMID: 2043172.

In vitro protocol:

TBD

In vivo protocol:

1: Wascher TC, Dittrich P, Kukovetz WR. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. PubMed PMID: 1620247. 2: Wascher TC, Dittrich P, Kukovetz WR. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. PubMed PMID: 2043172.