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MedKoo Cat#: 558692 | Name: SIG1459

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIG1459 is a phytyl-cysteine derived TLR2 modulator with anti-acne activity.

Chemical Structure

SIG1459
SIG1459
CAS#2234902-05-5

Theoretical Analysis

MedKoo Cat#: 558692

Name: SIG1459

CAS#: 2234902-05-5

Chemical Formula: C29H50N2Na2O5S

Exact Mass: 584.3236

Molecular Weight: 584.77

Elemental Analysis: C, 59.57; H, 8.62; N, 4.79; Na, 7.86; O, 13.68; S, 5.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SIG-1459; SIG 1459; SIG1459
IUPAC/Chemical Name
sodium (((1R)-1-carboxylato-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)-L-prolinate
InChi Key
LPHCSGBRSZXLCB-UFJNKAIOSA-L
InChi Code
InChI=1S/C29H52N2O5S.2Na/c1-21(2)10-6-11-22(3)12-7-13-23(4)14-8-15-24(5)17-19-37-20-25(27(32)33)30-29(36)31-18-9-16-26(31)28(34)35;;/h17,21-23,25-26H,6-16,18-20H2,1-5H3,(H,30,36)(H,32,33)(H,34,35);;/q;2*+1/p-2/b24-17+;;/t22?,23?,25-,26-;;/m0../s1
SMILES Code
O=C(N[C@H](C(O[Na])=O)CSC/C=C(CCCC(C)CCCC(CCCC(C)C)C)\C)N1[C@H](C(O[Na])=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 584.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fernández JR, Webb C, Rouzard K, Healy J, Tamura M, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Pérez E. SIG1459: A novel phytyl-cysteine derived TLR2 modulator with in vitro and clinical anti-acne activity. Exp Dermatol. 2018 Sep;27(9):993-999. doi: 10.1111/exd.13692. Epub 2018 Jul 25. PubMed PMID: 29797368.