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MedKoo Cat#: 573794 | Name: Amlodipine mesylate monohydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amlodipine mesylate monohydrate is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.

Chemical Structure

Amlodipine mesylate monohydrate
Amlodipine mesylate monohydrate
CAS#440358-84-9 (mesylate hydrate)

Theoretical Analysis

MedKoo Cat#: 573794

Name: Amlodipine mesylate monohydrate

CAS#: 440358-84-9 (mesylate hydrate)

Chemical Formula: C21H31ClN2O9S

Exact Mass: 522.1439

Molecular Weight: 522.99

Elemental Analysis: C, 48.23; H, 5.97; Cl, 6.78; N, 5.36; O, 27.53; S, 6.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
246852-12-0 (mesylate) 440358-84-9 (mesylate hydrate) 88150-47-4 (maleate)
Synonym
Amlodipine mesylate monohydrate
IUPAC/Chemical Name
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monomethanesulfonate, monohydrate
InChi Key
LGWOIMCQWJLZIT-UHFFFAOYSA-N
InChi Code
1S/C20H25ClN2O5.CH4O3S.H2O/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;1-5(2,3)4;/h5-8,17,23H,4,9-11,22H2,1-3H3;1H3,(H,2,3,4);1H2
SMILES Code
CCOC(=O)C1=C(NC(=C(C1c2ccccc2Cl)C(=O)OC)C)COCCN.CS(=O)(=O)O.O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 522.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gottwald-Hostalek U, Sun N, Barho C, Hildemann S. Management of Hypertension With a Fixed-Dose (Single-Pill) Combination of Bisoprolol and Amlodipine. Clin Pharmacol Drug Dev. 2017 Jan;6(1):9-18. doi: 10.1002/cpdd.309. Epub 2016 Oct 26. PubMed PMID: 27653022. 2: van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. Review. PubMed PMID: 9156957.