| 
                                                    Solvent | 
                                                    mg/mL | 
                                                    mM | 
                                                    comments | 
                                                
                                            
                                            
                                            
                                                | Solubility | 
                                            
                                                                                            
                                                    | DMSO | 
                                                    15.0 | 
                                                    27.14 | 
                                                     | 
                                                
                                                                                            
                                                    | DMF | 
                                                    5.0 | 
                                                    9.05 | 
                                                     | 
                                                
                                                                                        
                                        
                                        
                                            Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
                                        
                                     
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        552.66
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                                                            
                                
                                    1: Kim NY, Mohan CD, Chinnathambi A, Alharbi SA, Sethi G, Rangappa KS, Ahn KS. Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity. Molecules. 2022 Jun 14;27(12):3824. doi: 10.3390/molecules27123824. PMID: 35744950; PMCID: PMC9227563.
2: Kim NY, Sethi G, Um JY, Ahn KS. Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells. Int J Mol Sci. 2023 Sep 5;24(18):13713. doi: 10.3390/ijms241813713. PMID: 37762016; PMCID: PMC10531000.
3: Park SJ, Park JH, Han A, Davaatseren M, Kim HJ, Kim MS, Hur HJ, Sung MJ, Hwang JT, Yang HJ, Kwon DY. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase. Cell Biochem Funct. 2015 Jun;33(4):220-5. doi: 10.1002/cbf.3107. Epub 2015 Apr 23. PMID: 25914364.
4: Xiao S, Xu X, Wei X, Xin J, Li S, Lv Y, Chen W, Yuan W, Xie B, Zu X, Shen Y. Comprehensive Metabolic Profiling of Euphorbiasteroid in Rats by Integrating UPLC-Q/TOF-MS and NMR as Well as Microbial Biotransformation. Metabolites. 2022 Sep 2;12(9):830. doi: 10.3390/metabo12090830. PMID: 36144234; PMCID: PMC9504842.
5: Choi JS, Kang NS, Min YK, Kim SH. Euphorbiasteroid reverses P-glycoprotein- mediated multi-drug resistance in human sarcoma cell line MES-SA/Dx5. Phytother Res. 2010 Jul;24(7):1042-6. doi: 10.1002/ptr.3073. PMID: 19960428.
6: Jiang M, Liu Q, Zhang Y, Wang H, Zhang J, Chen M, Yue Z, Wang Z, Wei X, Shi S, Wang M, Hou Y, Wang Z, Sheng F, Tian N, Wang Y. Construction of magnetic drug delivery system and its potential application in tumor theranostics. Biomed Pharmacother. 2022 Oct;154:113545. doi: 10.1016/j.biopha.2022.113545. Epub 2022 Aug 22. PMID: 36007274.