Katacalcin | CAS# 85916-47-8 | calcitonin precursor peptide

MedKoo Cat#: 414817 | Name: Katacalcin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Katacalcin is a cleavage product of CALCA gene product calcitonin. It is a calcitonin precursor peptide.

Chemical Structure

Katacalcin

CAS#85916-47-8

Theoretical Analysis

MedKoo Cat#: 414817

Name: Katacalcin

CAS#: 85916-47-8

Chemical Formula: C97H154N34O36S2

Exact Mass: 2435.0706

Molecular Weight: 2436.62

Elemental Analysis: C, 47.81; H, 6.37; N, 19.55; O, 23.64; S, 2.63

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Synonym

Katacalcin; CCAP; Pdn-21; hCCAP

IUPAC/Chemical Name

(15S,18S,27S)-27-amino-3-((1-(((S)-1-((S)-2-(((5S,8S,11S,14S)-5-((S)-2-(((S)-5-amino-1-(((S)-4-amino-1-(((S)-1-(((S)-3-amino-1-carboxy-3-oxopropyl)amino)-1-oxopropan-2-yl)amino)-1,4-dioxobutan-2-yl)amino)-1,5-dioxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-15-(1H-imidazol-5-yl)-11-isopropyl-8-methoxy-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)carbamoyl)pyrrolidin-1-yl)-5-guanidino-1-oxopentan-2-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)carbamoyl)-9-(2-carboxyethyl)-15-(carboxymethyl)-6-(3-guanidinopropyl)-18,21-bis(hydroxymethyl)-12-isobutyl-24-(2-(methylthio)ethyl)-5,8,11,14,17,20,23,26-octaoxo-4,7,10,13,16,19,22,25-octaazanonacosanedioic acid

InChi Key

BOARIOLZPFSAQJ-NQSKQZERSA-N

InChi Code

InChI=1S/C97H154N34O36S2/c1-43(2)29-55(119-83(154)60(36-72(143)144)123-86(157)62(39-132)127-87(158)63(40-133)126-79(150)52(21-27-168-7)113-75(146)48(98)32-70(139)140)81(152)115-51(18-20-69(137)138)77(148)114-49(13-9-23-108-96(102)103)76(147)122-59(35-71(141)142)84(155)120-56(30-46-37-106-41-110-46)82(153)117-53(14-10-24-109-97(104)105)93(163)130-25-12-16-65(130)89(160)124-57(31-47-38-107-42-111-47)85(156)128-73(44(3)4)90(161)129-92(167-6)91(162)118-54(22-28-169-8)94(164)131-26-11-15-64(131)88(159)116-50(17-19-66(99)134)78(149)121-58(33-67(100)135)80(151)112-45(5)74(145)125-61(95(165)166)34-68(101)136/h37-38,41-45,48-65,73,92,132-133H,9-36,39-40,98H2,1-8H3,(H2,99,134)(H2,100,135)(H2,101,136)(H,106,110)(H,107,111)(H,112,151)(H,113,146)(H,114,148)(H,115,152)(H,116,159)(H,117,153)(H,118,162)(H,119,154)(H,120,155)(H,121,149)(H,122,147)(H,123,157)(H,124,160)(H,125,145)(H,126,150)(H,127,158)(H,128,156)(H,129,161)(H,137,138)(H,139,140)(H,141,142)(H,143,144)(H,165,166)(H4,102,103,108)(H4,104,105,109)/t45-,48-,49?,50-,51?,52?,53-,54-,55?,56?,57-,58-,59?,60-,61-,62-,63?,64-,65-,73-,92-/m0/s1

SMILES Code

CO[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)C)=O)CC(N)=O)=O)CCC(N)=O)=O)=O)CCSC)=O)NC([C@H](C(C)C)NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC(C(NC(C(NC(C(NC(C(NC(C(NC([C@@H](NC([C@@H](NC(C(NC(C(NC([C@H](CC(O)=O)N)=O)CCSC)=O)CO)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)Cc3[nH]cnc3)=O)CCCNC(N)=N)=O)=O)Cc4[nH]cnc4)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,436.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hillyard CJ, Myers C, Abeyasekera G, Stevvensvenson JC, Craig RK, MacIntyre I. Katacalcin: a new plasma calcium-lowering hormone. Lancet. 1983 Apr 16;1(8329):846-8. doi: 10.1016/s0140-6736(83)91387-9. PMID: 6132180. 2: Shibusawa K. [Katacalcin]. Kango. 1983 Sep;35(10):89. Japanese. PMID: 6563219. 3: Zdrojewicz Z, Januszewski A. Katakalcyna--budowa, wydzielanie i znaczenie kliniczne [Katacalcin--structure, secretion and clinical significance]. Postepy Hig Med Dosw. 1994;48(4):371-80. Polish. PMID: 7638091. 4: Oberhoffer M, Vogelsang H, Jäger L, Reinhart K. Katacalcin and calcitonin immunoreactivity in different types of leukocytes indicate intracellular procalcitonin content. J Crit Care. 1999 Mar;14(1):29-33. doi: 10.1016/s0883-9441(99)90005-9. PMID: 10102721. 5: Saggese G, Bertelloni S, Baroncelli GI, Buggiani B, Gualtieri M, Paci A. Livelli di katacalcina nei bambini normali e nella spasmofilia [Katacalcin levels in healthy children and children with spasmophilia]. Minerva Pediatr. 1989 Sep;41(9):459-66. Italian. PMID: 2685535. 6: Ahrén B. Effects of calcitonin, katacalcin, and calcitonin gene-related peptide on basal and TSH-stimulated thyroid hormone secretion in the mouse. Acta Physiol Scand. 1989 Feb;135(2):133-7. doi: 10.1111/j.1748-1716.1989.tb08560.x. PMID: 2784248. 7: Angelucci F, Gruber SH, Mathé AA. A pilot study of rat brain regional distribution of calcitonin, katacalcin and calcitonin gene-related peptide before and after antipsychotic treatment. Neuropeptides. 2001 Oct- Dec;35(5-6):285-91. doi: 10.1054/npep.2001.0876. PMID: 12030813. 8: Conlon JM, McGregor GP, Wallin G, Grimelius L, Thim L. Molecular forms of katacalcin, calcitonin gene-related peptide and gastrin-releasing peptide, in a human medullary thyroid carcinoma. Cancer Res. 1988 May 1;48(9):2412-6. PMID: 3258543. 9: Woloszczuk W, Schuh H, Kovarik J. Determination of circulating monomeric katacalcin and calcitonin: physiological studies in normal subjects. J Clin Chem Clin Biochem. 1986 Jul;24(7):451-5. doi: 10.1515/cclm.1986.24.7.451. PMID: 3755463. 10: di Sant'Agnese PA, de Mesy Jensen KL, Ackroyd RK. Calcitonin, katacalcin, and calcitonin gene-related peptide in the human prostate. An immunocytochemical and immunoelectron microscopic study. Arch Pathol Lab Med. 1989 Jul;113(7):790-6. PMID: 2787149.