KBR 2822 | CAS#126988-60-1 | esterase inhibitor

MedKoo Cat#: 558181 | Name: KBR 2822

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KBR 2822 is an esterase inhibitor that causes exacerbation (promotion) of toxic and traumatic axonopathies.

Chemical Structure

KBR 2822

CAS#126988-60-1

Theoretical Analysis

MedKoo Cat#: 558181

Name: KBR 2822

CAS#: 126988-60-1

Chemical Formula: C9H15ClF3O3PS

Exact Mass: 326.0100

Molecular Weight: 326.69

Elemental Analysis: C, 33.09; H, 4.63; Cl, 10.85; F, 17.45; O, 14.69; P, 9.48; S, 9.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KBR 2822;

IUPAC/Chemical Name

Phosphorothioic acid, O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester

InChi Key

DEMICWQHGWSYPB-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H15ClF3O3PS/c1-3-5-18-17(14,15-4-2)16-7-6-8(11,12)9(7,10)13/h7H,3-6H2,1-2H3

SMILES Code

O=P(OCC)(SCCC)OC1C(F)(Cl)C(F)(F)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jokanovic M, Moretto A, Lotti M. Repeated low doses of O-(2-chloro-2,3,3 trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) do not cause neuropathy in hens. Arch Toxicol. 1998;72(2):93-6. PubMed PMID: 9456080. 2: Moretto A, Bertolazzi M, Lotti M. The phosphorothioic acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester exacerbates organophosphate polyneuropathy without inhibition of neuropathy target esterase. Toxicol Appl Pharmacol. 1994 Nov;129(1):133-7. PubMed PMID: 7974486.