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MedKoo Cat#: 565607 | Name: AITC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AITC is a transient receptor potential subfamily a1 (trpa1) channel activator, leading to rapid trpa1 desensitization and internalization

Chemical Structure

AITC
AITC
CAS#57-06-7

Theoretical Analysis

MedKoo Cat#: 565607

Name: AITC

CAS#: 57-06-7

Chemical Formula: C4H5NS2•

Exact Mass: 99.0143

Molecular Weight: 99.15

Elemental Analysis: C, 48.46; H, 5.08; N, 14.13; S, 32.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AITC
IUPAC/Chemical Name
Allyl isothiocyanate
InChi Key
ZOJBYZNEUISWFT-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2
SMILES Code
C=CCN=C=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 99.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Agrawal SS, Yallatikar T, Gurjar P. Reversed-phase high-performance liquid chromatographic method development and validation for allyl isothiocyanate estimation in phytosomes of Brassica nigra extract. J Adv Pharm Technol Res. 2019 Jul-Sep;10(3):126-131. doi: 10.4103/japtr.JAPTR_382_18. PubMed PMID: 31334095; PubMed Central PMCID: PMC6621346. 2: Miyano K, Shiraishi S, Minami K, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y. Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways. Int J Mol Sci. 2019 Jul 3;20(13). pii: E3271. doi: 10.3390/ijms20133271. PubMed PMID: 31277262. 3: Long L, Yao H, Tian J, Luo W, Yu X, Yi F, Chen Q, Xie J, Zhong N, Chung KF, Lai K. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. Respir Res. 2019 Jun 6;20(1):112. doi: 10.1186/s12931-019-1077-z. PubMed PMID: 31170994; PubMed Central PMCID: PMC6554907. 4: Andrei SR, Ghosh M, Sinharoy P, Damron DS. Stimulation of TRPA1 attenuates ischemia-induced cardiomyocyte cell death through an eNOS-mediated mechanism. Channels (Austin). 2019 Dec;13(1):192-206. doi: 10.1080/19336950.2019.1623591. PubMed PMID: 31161862; PubMed Central PMCID: PMC6557600. 5: Eigenbrod O, Debus KY, Reznick J, Bennett NC, Sánchez-Carranza O, Omerbašić D, Hart DW, Barker AJ, Zhong W, Lutermann H, Katandukila JV, Mgode G, Park TJ, Lewin GR. Rapid molecular evolution of pain insensitivity in multiple African rodents. Science. 2019 May 31;364(6443):852-859. doi: 10.1126/science.aau0236. PubMed PMID: 31147513. 6: Hansted AK, Bhatt DK, Olesen J, Jensen LJ, Jansen-Olesen I. Effect of TRPA1 activator allyl isothiocyanate (AITC) on rat dural and pial arteries. Pharmacol Rep. 2019 Aug;71(4):565-572. doi: 10.1016/j.pharep.2019.02.015. Epub 2019 Feb 21. PubMed PMID: 31132686. 7: Dalenogare DP, Ferro PR, De Prá SDT, Rigo FK, de David Antoniazzi CT, de Almeida AS, Damiani AP, Strapazzon G, de Oliveira Sardinha TT, Galvani NC, Boligon AA, de Andrade VM, da Silva Brum E, Oliveira SM, Trevisan G. Antinociceptive activity of Copaifera officinalis Jacq. L oil and kaurenoic acid in mice. Inflammopharmacology. 2019 May 16. doi: 10.1007/s10787-019-00588-3. [Epub ahead of print] PubMed PMID: 31098702. 8: Schepetkin IA, Kirpotina LN, Khlebnikov AI, Balasubramanian N, Quinn MT. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds. Molecules. 2019 May 10;24(9). pii: E1809. doi: 10.3390/molecules24091809. PubMed PMID: 31083328; PubMed Central PMCID: PMC6539273. 9: Hooper JS, Stanford KR, Alencar PA, Alves NG, Breslin JW, Dean JB, Morris KF, Taylor-Clark TE. Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat. J Physiol. 2019 Jul;597(13):3255-3279. doi: 10.1113/JP278085. Epub 2019 May 30. PubMed PMID: 31077371; PubMed Central PMCID: PMC6602842. 10: Kameda T, Zvick J, Vuk M, Sadowska A, Tam WK, Leung VY, Bölcskei K, Helyes Z, Applegate LA, Hausmann ON, Klasen J, Krupkova O, Wuertz-Kozak K. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. Int J Mol Sci. 2019 Apr 10;20(7). pii: E1767. doi: 10.3390/ijms20071767. PubMed PMID: 30974795; PubMed Central PMCID: PMC6480240. 11: Pergher D, Picolotto A, Rosales PF, Machado KG, Cerbaro AF, França RT, Salvador M, Roesch-Ely M, Tasso L, Figueiredo JG, Moura S. Antinociceptive and antioxidant effects of extract enriched with active indole alkaloids from leaves of Tabernaemontana catharinensis A. DC. J Ethnopharmacol. 2019 Jul 15;239:111863. doi: 10.1016/j.jep.2019.111863. Epub 2019 Apr 9. PubMed PMID: 30974203. 12: Yang J, Li Y, Yan W, Li W, Qiu Q, Ye H, Chen L. Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation. J Biol Chem. 2019 May 17;294(20):8161-8170. doi: 10.1074/jbc.RA118.006325. Epub 2019 Apr 2. PubMed PMID: 30940730; PubMed Central PMCID: PMC6527155. 13: Sahin N, Orhan C, Erten F, Tuzcu M, Defo Deeh PB, Ozercan IH, Juturu V, Kazim S. Effects of allyl isothiocyanate on insulin resistance, oxidative stress status, and transcription factors in high-fat diet/streptozotocin-induced type 2 diabetes mellitus in rats. J Biochem Mol Toxicol. 2019 Jul;33(7):e22328. doi: 10.1002/jbt.22328. Epub 2019 Mar 30. PubMed PMID: 30927557. 14: Thangarasu R, Pachaiappan P, Subbaiyan T. Anti-Estrogenic and Anti-Cell Proliferative Effect of Allyl Isothiocyanate in Chemoprevention of Chemically Induced Mammary Carcinogenesis in Rats. Pathol Oncol Res. 2019 Mar 20. doi: 10.1007/s12253-019-00638-9. [Epub ahead of print] PubMed PMID: 30895454. 15: Torrijos R, Nazareth TM, Pérez J, Mañes J, Meca G. Development of a Bioactive Sauce Based on Oriental Mustard Flour with Antifungal Properties for Pita Bread Shelf Life Improvement. Molecules. 2019 Mar 14;24(6). pii: E1019. doi: 10.3390/molecules24061019. PubMed PMID: 30875724; PubMed Central PMCID: PMC6471135. 16: Wang L, Mazzola M. Effect of Soil Physical Conditions on Emission of Allyl Isothiocyanate and Subsequent Microbial Inhibition in Response to Brassicaceae Seed Meal Amendment. Plant Dis. 2019 May;103(5):846-852. doi: 10.1094/PDIS-08-18-1389-RE. Epub 2019 Mar 11. PubMed PMID: 30856078. 17: Quiles JM, Nazareth TM, Luz C, Luciano FB, Mañes J, Meca G. Development of an Antifungal and Antimycotoxigenic Device Containing Allyl Isothiocyanate for Silo Fumigation. Toxins (Basel). 2019 Mar 1;11(3). pii: E137. doi: 10.3390/toxins11030137. PubMed PMID: 30823642; PubMed Central PMCID: PMC6468390. 18: Ugolini L, Pagnotta E, Matteo R, Malaguti L, Di Francesco A, Lazzeri L. Brassica meal-derived allyl-isothiocyanate postharvest application: influence on strawberry nutraceutical and biochemical parameters. J Sci Food Agric. 2019 Jul;99(9):4235-4241. doi: 10.1002/jsfa.9654. Epub 2019 Mar 19. PubMed PMID: 30801703. 19: De Logu F, Li Puma S, Landini L, Tuccinardi T, Poli G, Preti D, De Siena G, Patacchini R, Tsagareli MG, Geppetti P, Nassini R. The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. Pharmacol Res. 2019 Apr;142:127-139. doi: 10.1016/j.phrs.2019.02.019. Epub 2019 Feb 19. PubMed PMID: 30794923. 20: Rai SK, Sharma R, Patil RD, Periasamy S, Rasmussen LH, Padwad YS, Kumari A, Bhar R. Allyl-isothiocyanate ameliorates the pre-neoplastic changes induced by the fern Dryopteris nigropalaceae on experimental feeding in Guinea pigs. Res Vet Sci. 2019 Jun;124:24-31. doi: 10.1016/j.rvsc.2019.02.003. Epub 2019 Feb 16. Erratum in: Res Vet Sci. 2019 Mar 29;124:239. PubMed PMID: 30782570.