AIU2008 is a novel FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing improved anti-leukemic efficacy in FLT3-ITD-positive AML cells, specifically inhibiting cell growth and apoptotic death, down-regulating DNA repair genes involved in homologous recombination and non-homologous end joining.
MedKoo Cat#: 465347
Name: AIU2008
CAS#: unknown
Chemical Formula: C19H13FN2O
Exact Mass: 304.1012
Molecular Weight: 304.32
Elemental Analysis: C, 74.99; H, 4.31; F, 6.24; N, 9.21; O, 5.26
The following data is based on the product molecular weight 304.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
