SP-8203 | CAS#1176758-04-5 | oxygen species inhiitor

MedKoo Cat#: 596056 | Name: SP-8203

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant. SP-8203 has been used in trials studying the treatment of Ischemic Stroke.

Chemical Structure

SP-8203

CAS#1176758-04-5

Theoretical Analysis

MedKoo Cat#: 596056

Name: SP-8203

CAS#: 1176758-04-5

Chemical Formula: C28H34N6O5

Exact Mass: 534.2591

Molecular Weight: 534.61

Elemental Analysis: C, 62.91; H, 6.41; N, 15.72; O, 14.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SP-8203; J3.046.690J; SP8203; SP 8203;

IUPAC/Chemical Name

N-(3-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propyl)-N-(4-((3-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)propyl)amino)butyl)acetamide

InChi Key

SJZBPVOSFYUHFV-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H34N6O5/c1-20(35)32(17-9-19-34-26(37)22-11-3-5-13-24(22)31-28(34)39)16-7-6-14-29-15-8-18-33-25(36)21-10-2-4-12-23(21)30-27(33)38/h2-5,10-13,29H,6-9,14-19H2,1H3,(H,30,38)(H,31,39)

SMILES Code

CC(N(CCCN1C(NC2=C(C=CC=C2)C1=O)=O)CCCCNCCCN3C(NC4=C(C=CC=C4)C3=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 534.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Han SY, Yoon I, Chin YW, Cho IW, Lee MG, Choi YH. Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily. Xenobiotica. 2012 Oct;42(10):1017-27. doi: 10.3109/00498254.2012.663117. Epub 2012 May 9. PubMed PMID: 22568632. 2: Noh SJ, Lee JM, Lee KS, Hong HS, Lee CK, Cho IH, Kim HS, Suh YH. SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor. Pharmacol Biochem Behav. 2011 Nov;100(1):73-80. doi: 10.1016/j.pbb.2011.07.018. Epub 2011 Aug 1. PubMed PMID: 21835192. 3: Noh SJ, Lee SH, Shin KY, Lee CK, Cho IH, Kim HS, Suh YH. SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia. Pharmacol Biochem Behav. 2011 Mar;98(1):150-4. doi: 10.1016/j.pbb.2010.12.014. Epub 2010 Dec 21. PubMed PMID: 21172384. 4: Lee JH, Choi YH, Suh JH, Kang HE, Lee TH, Cho IH, Lee MG. Dose-dependent pharmacokinetics of SP-8203 in rats. Biopharm Drug Dispos. 2010 Jul;31(5-6):358-61. doi: 10.1002/bdd.713. PubMed PMID: 20578211.