MedKoo Cat#: 577220 | Name: Metaraminol oxalate dihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metaraminol is a selective α₁-adrenergic receptor agonist with vasoconstrictive properties. It primarily increases blood pressure by inducing peripheral vasoconstriction, making it useful in treating hypotension during anesthesia or shock. Additionally, metaraminol has some indirect sympathomimetic activity by stimulating norepinephrine release, further enhancing its pressor effects. Unlike direct-acting catecholamines, it has a longer duration of action due to slower metabolism.

Chemical Structure

Metaraminol oxalate dihydrate
CAS#5967-53-3 (oxalate dihydrate)

Theoretical Analysis

MedKoo Cat#: 577220

Name: Metaraminol oxalate dihydrate

CAS#: 5967-53-3 (oxalate dihydrate)

Chemical Formula: C11H19NO8

Exact Mass: 293.1111

Molecular Weight: 293.27

Elemental Analysis: C, 45.05; H, 6.53; N, 4.78; O, 43.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Metaraminol oxalate dihydrate
IUPAC/Chemical Name
(alphaR)-alpha-((1S)-1-Aminoethyl)-3-hydroxybenzenemethanol oxalate dihydrate
InChi Key
JLDOUEIDNZKSQH-YDYUUSCQSA-N
InChi Code
InChI=1S/C9H13NO2.C2H2O4/c1-6(10)9(12)7-3-2-4-8(11)5-7;3-1(4)2(5)6/h2-6,9,11-12H,10H2,1H3;(H,3,4)(H,5,6)/t6-,9-;/m0./s1
SMILES Code
C[C@H](N)[C@H](O)c1cccc(O)c1.OC(=O)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hill DW, Hyde WG, Kind AJ, Greulich D, Hopkins S. Development of analytical methods for the detection of metaraminol in the horse. J Anal Toxicol. 2000 May-Jun;24(4):281-8. PubMed PMID: 10872576. 2: Johnson GE, Pugsley TA. Studies on the interrelationship between the syntheses of noradrenaline and metaraminol. Br J Pharmacol. 1970 May;39(1):167-74. PubMed PMID: 4317857; PubMed Central PMCID: PMC1702959. 3: Natalini G, Schivalocchi V, Rosano A, Taranto M, Pletti C, Bernardini A. Norepinephrine and metaraminol in septic shock: a comparison of the hemodynamic effects. Intensive Care Med. 2005 May;31(5):634-7. Epub 2005 Apr 1. PubMed PMID: 15803299. 4: Critchley LA, Yu SC. A comparative study of three different methods of administering metaraminol during spinal anaesthesia in the elderly. Anaesth Intensive Care. 2001 Apr;29(2):141-8. PubMed PMID: 11314833.