NPD8733 | CAS#696655-62-6 | cancer cell-enhanced fibroblast migration inhibitor

MedKoo Cat#: 565548 | Name: NPD8733

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97

Chemical Structure

NPD8733

CAS#696655-62-6

Theoretical Analysis

MedKoo Cat#: 565548

Name: NPD8733

CAS#: 696655-62-6

Chemical Formula: C18H15NO4

Exact Mass: 309.1001

Molecular Weight: 309.32

Elemental Analysis: C, 69.89; H, 4.89; N, 4.53; O, 20.69

Price and Availability

Size	Price	Availability
25mg	USD 450.00	2 Weeks
100mg	USD 1,250.00	2 Weeks
1g	USD 4,250.00	2 Weeks

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Related CAS #

No Data

Synonym

NPD8733; NPD 8733; NPD-8733

IUPAC/Chemical Name

N-(2-(4-Methoxybenzoyl)benzofuran-3-yl)acetamide

InChi Key

NQZBUYPGHZTWIR-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15NO4/c1-11(20)19-16-14-5-3-4-6-15(14)23-18(16)17(21)12-7-9-13(22-2)10-8-12/h3-10H,1-2H3,(H,19,20)

SMILES Code

CC(NC1=C(C(C2=CC=C(OC)C=C2)=O)OC3=CC=CC=C13)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration.

In vitro activity:

This study identified NPD8733 as an inhibitor of cancer cell-enhanced fibroblast migration. This inhibition was observed not only in a wound-healing co-culture assay but also in a Transwell migration assay. Using NPD8733 and a structurally similar but inactive derivative, NPD8126, on immobilized beads, we found that NPD8733, but not NPD8126, specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. Reference: J Biol Chem. 2019 Mar 1;294(9):2988-2996. https://pubmed.ncbi.nlm.nih.gov/30610116/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 309.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N. A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. J Biol Chem. 2019 Mar 1;294(9):2988-2996. doi: 10.1074/jbc.RA118.004741. Epub 2019 Jan 4. PMID: 30610116; PMCID: PMC6398144.

In vitro protocol:

In vivo protocol:

TBD

1: Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N. A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. J Biol Chem. 2019 Mar 1;294(9):2988-2996. doi: 10.1074/jbc.RA118.004741. Epub 2019 Jan 4. PubMed PMID: 30610116; PubMed Central PMCID: PMC6398144.