Palatinit | CAS#64519-82-0 | disaccharide

MedKoo Cat#: 585029 | Name: Palatinit

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Palatinit is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside that affects de- and remineralization and is non-cariogenic.

Chemical Structure

Palatinit

CAS#64519-82-0

Theoretical Analysis

MedKoo Cat#: 585029

Name: Palatinit

CAS#: 64519-82-0

Chemical Formula: C33H51N9O7

Exact Mass: 685.3911

Molecular Weight: 685.83

Elemental Analysis: C, 57.79; H, 7.50; N, 18.38; O, 16.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Palatinit; Isomalt

IUPAC/Chemical Name

6-O-alpha-D-Glucopyranosyl-D-glucitol mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol

InChi Key

NNFNVJXYWKWZTB-RDFDVFKPSA-N

InChi Code

InChI=1S/C33H51N9O7/c1-3-20(2)27(32(48)49)40-30(46)25-14-9-17-42(25)31(47)23(18-21-10-5-4-6-11-21)39-29(45)24-13-8-16-41(24)26(43)19-38-28(44)22(34)12-7-15-37-33(35)36/h4-6,10-11,20,22-25,27H,3,7-9,12-19,34H2,1-2H3,(H,38,44)(H,39,45)(H,40,46)(H,48,49)(H4,35,36,37)/t20?,22-,23?,24?,25?,27?/m0/s1

SMILES Code

O=C(NCC(N1C(CCC1)C(NC(CC2=CC=CC=C2)C(N(CCC3)C3C(NC(C(C)CC)C(O)=O)=O)=O)=O)=O)[C@@H](N)CCCNC(N)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 685.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kirchgessner M, Müller HL. [Palatinit--digestibility and energy utilization in model experiments with sows]. Z Ernahrungswiss. 1983 Dec;22(4):234-40. German. PubMed PMID: 6659593. 2: Ghanavati R, Taheri A, Homayouni A. Anomalous dissolution behavior of celecoxib in PVP/Isomalt solid dispersions prepared using spray drier. Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:501-511. doi: 10.1016/j.msec.2016.11.042. Epub 2016 Nov 14. PubMed PMID: 28024614. 3: Herfarth H, Klingebiel L, Juhr NC, Grossklaus R. Dose dependency of fermentation and the extent of renal excretion of palatinit (isomalt) in rats with respect to its energy value. Z Ernahrungswiss. 1994 Sep;33(3):185-94. PubMed PMID: 7810177. 4: Gehring F, Karle EJ. [Sweetening agent, Palatinit under specific consideration as to microbiological and caries-prophylactic aspects]. Z Ernahrungswiss. 1981 Jun;20(2):96-106. German. PubMed PMID: 7269663. 5: Fritz M, Siebert G, Kasper H. Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit. Br J Nutr. 1985 Sep;54(2):389-400. PubMed PMID: 4063326. 6: Zinner PM, Kirchgessner M. [Energetic utilization of Palatinit]. Z Ernahrungswiss. 1982 Dec;21(4):272-8. German. PubMed PMID: 7180044. 7: Ziesenitz SC. Bioavailability of glucose from Palatinit. Z Ernahrungswiss. 1983 Sep;22(3):185-94. PubMed PMID: 6417920. 8: Zhao N, Xu Y, Wang K, Zheng S. Synthesis of Isomalto-Oligosaccharides by Pichia pastoris Displaying the Aspergillus niger α-Glucosidase. J Agric Food Chem. 2017 Nov 1;65(43):9468-9474. doi: 10.1021/acs.jafc.7b04140. Epub 2017 Oct 23. PubMed PMID: 28980463. 9: Tan EH, Parmentier J, Low A, Möschwitzer JP. Downstream drug product processing of itraconazole nanosuspension: Factors influencing tablet material properties and dissolution of compacted nanosuspension-layered sugar beads. Int J Pharm. 2017 Oct 30;532(1):131-138. doi: 10.1016/j.ijpharm.2017.08.107. Epub 2017 Aug 30. PubMed PMID: 28859940. 10: Gostner A, Schäffer V, Theis S, Menzel T, Lührs H, Melcher R, Schauber J, Kudlich T, Dusel G, Dorbath D, Kozianowski G, Scheppach W. Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers. Br J Nutr. 2005 Oct;94(4):575-81. PubMed PMID: 16197583. 11: Mayhew EJ, Schmidt SJ, Lee SY. Sensory and Physical Effects of Sugar Reduction in a Caramel Coating System. J Food Sci. 2017 Aug;82(8):1935-1946. doi: 10.1111/1750-3841.13785. Epub 2017 Jul 4. PubMed PMID: 28675759. 12: Nilsson U, Jägerstad M. Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies. Br J Nutr. 1987 Sep;58(2):199-206. PubMed PMID: 3676242. 13: Gargouri W, Zmantar T, Kammoun R, Kechaou N, Ghoul-Mazgar S. Coupling xylitol with remineralizing agents improves tooth protection against demineralization but reduces antibiofilm effect. Microb Pathog. 2018 Oct;123:177-182. doi: 10.1016/j.micpath.2018.06.038. Epub 2018 Jun 26. PubMed PMID: 29959041. 14: Tuderman AK, Strachan CJ, Juppo AM. Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase. Int J Pharm. 2018 Mar 1;538(1-2):287-295. doi: 10.1016/j.ijpharm.2018.01.015. Epub 2018 Jan 16. PubMed PMID: 29341910. 15: Lengyel M, Balogh E, Szerőczei D, Dobó-Nagy C, Pápay Z, Stömmer V, Klebovich I, Antal I. Study on process parameters and optimization of microencapsulation based on phase separation. Eur J Pharm Sci. 2018 Sep 15;122:273-280. doi: 10.1016/j.ejps.2018.07.015. Epub 2018 Jul 5. PubMed PMID: 29981890. 16: Gau W, Kurz J, Müller L, Fischer E, Steinle G, Grupp U, Siebert G. [Analytical characterization of palatinit (author's transl)]. Z Lebensm Unters Forsch. 1979 Feb 26;168(2):125-30. German. PubMed PMID: 425707. 17: Gülzow HJ. [Anaerobic transformation of Palatinit by microorganisms of the human oral cavity]. Dtsch Zahnarztl Z. 1982 Aug;37(8):669-72. German. PubMed PMID: 6957291. 18: Ziesenitz SC. [Utilization of the sugar substitute Palatinit in metabolism]. Beitr Infusionther Klin Ernahr. 1986;16:120-32. German. PubMed PMID: 2945548. 19: Klingebiel L, Krüger D, Grossklaus R. Analysis of Palatinit (isomalt) and its monomers in rat intestinal samples by high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1990 Apr 27;527(1):238-43. PubMed PMID: 2365788. 20: Wang Q, Zhang H, Zhang Y. [Screening, identification and characterization of thermotolerant dextranase from a fungus]. Wei Sheng Wu Xue Bao. 2016 May 4;56(5):880-90. Chinese. PubMed PMID: 29727149.