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MedKoo Cat#: 573706 | Name: Altizide, (+)-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Altizide, (+)-, is a thiazide diuretic used to treat oedema and hypertension.

Chemical Structure

Altizide, (+)-
Altizide, (+)-
CAS#133585-76-9 ((+)- Isomer)

Theoretical Analysis

MedKoo Cat#: 573706

Name: Altizide, (+)-

CAS#: 133585-76-9 ((+)- Isomer)

Chemical Formula: C11H14ClN3O4S3

Exact Mass: 382.9835

Molecular Weight: 383.88

Elemental Analysis: C, 34.42; H, 3.68; Cl, 9.23; N, 10.95; O, 16.67; S, 25.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
133562-97-7 ((-)- Isomer) 133585-76-9 ((+)- Isomer) 5588-16-9 (racemate)
Synonym
Altizide, (+)-; (+)-Altizide
IUPAC/Chemical Name
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-((2-propen-1-ylthio)methyl)-, 1,1-dioxide, (+)-
InChi Key
VGLGVJVUHYTIIU-UHFFFAOYSA-N
InChi Code
1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)
SMILES Code
NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deventer K, Pozo OJ, Van Eenoo P, Delbeke FT. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis. J Chromatogr A. 2009 Mar 20;1216(12):2466-73. doi: 10.1016/j.chroma.2009.01.032. PubMed PMID: 19187939. 2: Degre S, Detry JM, Unger P, Cosyns J, Brohet C, Kormoss N. Effects of spironolactone-altizide on left ventricular hypertrophy. Acta Cardiol. 1998;53(5):261-7. PubMed PMID: 9922803. 3: Charneau J, Mendler M. [Acute necrotic pancreatitis and althiazide]. Gastroenterol Clin Biol. 1997;21(2):164-5. French. PubMed PMID: 9161489. 4: Poncelet P, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure. Am J Cardiol. 1990 Jun 19;65(23):33K-35K. PubMed PMID: 2191587. 5: Grünfeld JP, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide versus converting enzyme inhibitor (enalapril). Am J Cardiol. 1990 Jun 19;65(23):28K-32K. PubMed PMID: 2191586. 6: Sternon J. Spironolactone and altizide in systemic hypertension: ambulatory multicenter study. Am J Cardiol. 1990 Jun 19;65(23):24K-27K. PubMed PMID: 1972313. 7: Dueymes JM. Clinical update: spironolactone and altizide as monotherapy in systemic hypertension. Am J Cardiol. 1990 Jun 19;65(23):20K-23K. PubMed PMID: 2191585. 8: Mngola EN. The use of a spironolactone and althiazide combination (aldactacine) in the treatment of benign essential hypertension. J Int Med Res. 1980;8(3):199-204. PubMed PMID: 6993252. 9: Deventer K, Baele G, Van Eenoo P, Pozo OJ, Delbeke FT. Stability of selected chlorinated thiazide diuretics. J Pharm Biomed Anal. 2009 Feb 20;49(2):519-24. doi: 10.1016/j.jpba.2008.11.001. PubMed PMID: 19108977.