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MedKoo Cat#: 329402 | Name: Altizide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Altizide, also known as Aldactacine and P-1779, is a thiazide diuretic used to treat oedema and hypertension.

Chemical Structure

Altizide
Altizide
CAS#5588-16-9 (racemate)

Theoretical Analysis

MedKoo Cat#: 329402

Name: Altizide

CAS#: 5588-16-9 (racemate)

Chemical Formula: C11H14ClN3O4S3

Exact Mass: 382.9835

Molecular Weight: 383.88

Elemental Analysis: C, 34.42; H, 3.68; Cl, 9.23; N, 10.95; O, 16.67; S, 25.05

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Related CAS #
133562-97-7 ((-)- Isomer) 133585-76-9 ((+)- Isomer) 5588-16-9 (racemate)
Synonym
Altizide; P-1779; P 1779; P1779; Aldactacine; CB 8093; CB-8093; CB8093
IUPAC/Chemical Name
3-((allylthio)methyl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
InChi Key
VGLGVJVUHYTIIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)
SMILES Code
O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC=C)NS2(=O)=O)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sternon J. Spironolactone and altizide in systemic hypertension: ambulatory multicenter study. Am J Cardiol. 1990 Jun 19;65(23):24K-27K. doi: 10.1016/0002-9149(90)91273-9. PMID: 1972313. 2: Grünfeld JP, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide versus converting enzyme inhibitor (enalapril). Am J Cardiol. 1990 Jun 19;65(23):28K-32K. doi: 10.1016/0002-9149(90)91274-a. PMID: 2191586. 3: Poncelet P, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure. Am J Cardiol. 1990 Jun 19;65(23):33K-35K. doi: 10.1016/0002-9149(90)91275-b. PMID: 2191587. 4: Dueymes JM. Clinical update: spironolactone and altizide as monotherapy in systemic hypertension. Am J Cardiol. 1990 Jun 19;65(23):20K-23K. doi: 10.1016/0002-9149(90)91272-8. PMID: 2191585. 5: Deventer K, Pozo OJ, Van Eenoo P, Delbeke FT. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis. J Chromatogr A. 2009 Mar 20;1216(12):2466-73. doi: 10.1016/j.chroma.2009.01.032. Epub 2009 Jan 17. PMID: 19187939. 6: Deventer K, Baele G, Van Eenoo P, Pozo OJ, Delbeke FT. Stability of selected chlorinated thiazide diuretics. J Pharm Biomed Anal. 2009 Feb 20;49(2):519-24. doi: 10.1016/j.jpba.2008.11.001. Epub 2008 Nov 13. PMID: 19108977. 7: Gibelin P, Durand P, Baudouy M, Camous JP, Morand P. Efficacité et tolérance de l'énalapril comparées à celles de l'altizide associée à la spironolactone chez des patients atteints d'hypertension artérielle modérée [Efficacy and tolerability of enalapril compared to altizide combined with spironolactone in patients with moderate arterial hypertension]. Ann Cardiol Angeiol (Paris). 1986 May;35(5):279-83. French. PMID: 3019212. 8: Degre S, Detry JM, Unger P, Cosyns J, Brohet C, Kormoss N. Effects of spironolactone-altizide on left ventricular hypertrophy. Acta Cardiol. 1998;53(5):261-7. PMID: 9922803. 9: Béranger C, de Leiris J, Tapsoba A. Effets électrophysiologiques de l'association spironolactone-altizide sur le coeur isolé de rat [Electrophysiologic effects of a spironolactone-altizide combination on the isolated rat heart]. Arch Mal Coeur Vaiss. 1986 Jun;79(7):1117-21. French. PMID: 3096237. 10: Hartemann J, Richon J, Landes P, Ferry JM, Brunel G. L'utilisation d'une association aldactone-altizide en obstétrique: à propos d'une centaine d'observations [Use of combined aldactone-altizide in obstetrics: 100 cases]. Bull Fed Soc Gynecol Obstet Lang Fr. 1969 Jun-Aug;21(3):315-8. French. PMID: 5400372. 11: de Roquefeuil F, Goupil C. Aldactazine [Aldactazide]. Soins Cardiol. 1986 Jan;(35):I-II. French. PMID: 3634504. 12: Lekiefre J, Foucault M, Basin B, Delemotte M. Effets de l'association Aldactone micronisée-Altizide dans le traitement des oedèmes [Effects of the micronized aldactone - altizide combination in the treatment of edema]. Lille Med. 1966 Jun-Jul;11(6):730-3. French. PMID: 5942193. 13: Restivo O, Sindoni G, Ballati S, Foti V. Il trattamento dell'ipertensione arteriosa. Aspetti clinico-terapeutici di una nuova associazione: canrenoato di K-altizide-rescinnamina [Treatment of arterial hypertension. Clinico- therapeutical aspects of a new association: potassium cancreonate of altizide- rescinnamine]. Minerva Cardioangiol. 1973 Sep;21(9):585-604. Italian. PMID: 4147632. 14: Schohn DC, Jahn HA. Effects of a potassium-sparing/thiazide diuretic combination on cardiovascular reactivity to vasopressor agents. Am J Cardiol. 1990 Jun 19;65(23):14K-17K. doi: 10.1016/0002-9149(90)91270-g. PMID: 2353665. 15: Pieters R, Hunger SP, Boos J, Rizzari C, Silverman L, Baruchel A, Goekbuget N, Schrappe M, Pui CH. L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase. Cancer. 2011 Jan 15;117(2):238-49. doi: 10.1002/cncr.25489. Epub 2010 Sep 7. PMID: 20824725; PMCID: PMC3000881. 16: Soulié P, Gaudeau S. Traitement des oedèmes cardiaques par l'association aldactone micronisé-Altizide [Treatment of cardiac edemas by a combination of micronized aldactone and Altizide]. Coeur Med Interne. 1965 Apr;4(2):209-13. French. PMID: 5827838. 17: Caraman PL, Fabre JL, Maurice F, Netter P, Trechot P. Hypercalcémie sous altizide. A propos d'une observation chez une patiente porteuse d'une glomérulonéphrite extra-membraneuse, avec insuffisance rénale [Hypercalcemia from altizide. Apropos of a case in a patient with extramembranous glomerulonephritis and renal failure]. Therapie. 1983 Sep-Oct;38(5):563-4. French. PMID: 6670082. 18: Boissel JP, Collet JP, Lion L, Ducruet T, Moleur P, Luciani J, Milon H, Madonna O, Gillet J, Gerini P, et al. A randomized comparison of the effect of four antihypertensive monotherapies on the subjective quality of life in previously untreated asymptomatic patients: field trial in general practice. The OCAPI Study Group. Optimiser le Choix d'un Anti-hypertenseur de Première Intention. J Hypertens. 1995 Sep;13(9):1059-67. doi: 10.1097/00004872-199509000-00018. PMID: 8586825. 19: Doignon JL, Grognet JM, Thébault JJ, Caplain M, Capron MH, Pelletier B, Wehrlen M, Istin M. Pharmacocinétique chez le sujet sain de l'altizide et de la spironolactone en association fixe pour deux posologies [Pharmacokinetics in healthy subjects of althiazide and spironolactone in a fixed combination for 2 doses]. Therapie. 1990 Nov-Dec;45(6):475-81. French. PMID: 2080486. 20: Zhu M, Wang J, Chen C, Song Y, Pan J. Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter. Environ Sci Pollut Res Int. 2021 Feb;28(8):9598-9609. doi: 10.1007/s11356-020-11347-1. Epub 2020 Nov 5. PMID: 33150508.