Kirromycin is a polyketide antibiotic produced by Streptomyces collinus that functions as a potent inhibitor of bacterial protein synthesis. It exerts its effect by binding to elongation factor Tu (EF-Tu), stabilizing the EF-Tu·GDP·aminoacyl-tRNA complex on the ribosome, thereby preventing the release of EF-Tu and halting translation. This unique mechanism distinguishes kirromycin from ribosome-targeting antibiotics and has made it a valuable tool in studying EF-Tu function and antibiotic resistance mechanisms.
MedKoo Cat#: 584988
Name: Kirromycin
CAS#: 50935-71-2 (free acid)
Chemical Formula: C43H60N2O12
Exact Mass: 796.4146
Molecular Weight: 796.96
Elemental Analysis: C, 64.81; H, 7.59; N, 3.52; O, 24.09
The following data is based on the product molecular weight 796.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
