GSK-2229238 | CAS# | MetAP-2 inhibitor

MedKoo Cat#: 408003 | Name: GSK-2229238

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-2229238 is a MetAP-2 inhibitor.

Chemical Structure

GSK-2229238

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 408003

Name: GSK-2229238

CAS#: Unknown

Chemical Formula: C22H24F2N4O2

Exact Mass: 414.1867

Molecular Weight: 414.46

Elemental Analysis: C, 63.76; H, 5.84; F, 9.17; N, 13.52; O, 7.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GSK-2229238; GSK 2229238; GSK2229238;

IUPAC/Chemical Name

5,6-difluoro-3-(2-isopropoxy-4-(piperazin-1-yl)phenyl)-1H-indole-2-carboxamide

InChi Key

VLTSNEYKDGRFDU-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24F2N4O2/c1-12(2)30-19-9-13(28-7-5-26-6-8-28)3-4-14(19)20-15-10-16(23)17(24)11-18(15)27-21(20)22(25)29/h3-4,9-12,26-27H,5-8H2,1-2H3,(H2,25,29)

SMILES Code

CC(C)OC1=C(C2=C(C(N)=O)NC3=C2C=C(F)C(F)=C3)C=CC(N4CCNCC4)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 414.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Cowley, P.; Hales, N.; Ward, S. Highlights from the society for medicines research symposium held on December 9, 2010 at Nhli, London UK. Drugs Future 2011, 36, 543−549. 2. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini, Uwe Eckert, Manja Friese-Hamim, Rainer Kohl, Martin Lehmann, Birgitta Leuthner, Djordje Musil, Felix Rohdich, and Frank T. Zenke Publication Date (Web): April 2, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00041