NR-160 is a selective Histone Deacetylase 6 (HDAC6) Inhibitor with Bifurcated Capping Groups. NR-160 displayed only low cytotoxicity as a single agent against leukemia cell lines, it augmented the apoptosis induction of the proteasome inhibitor bortezomib in combination experiments significantly. Furthermore, a combinatorial high-throughput drug screen revealed significantly enhanced cytotoxicity when NR-160 was used in combination with epirubicin and daunorubicin. The synergistic effect in combination with bortezomib and anthracyclines highlights the potential of NR-160 in combination therapies.
MedKoo Cat#: 462849
Name: NR-160
CAS#: 2484895-50-1
Chemical Formula: C25H21F3N6O3
Exact Mass: 510.1627
Molecular Weight: 510.48
Elemental Analysis: C, 58.82; H, 4.15; F, 11.17; N, 16.46; O, 9.40
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 58.77 | |
| DMSO | 20.0 | 39.18 | |
| Ethanol | 1.0 | 1.96 |
The following data is based on the product molecular weight 510.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
