DDO-2117 | MLL1-WDR5 Blocker

MedKoo Cat#: 565239 | Name: DDO-2117

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DDO-2117 is a potent blocker of mixed lineage leukemia 1 (MLL1)-WDR5 interaction which inhibits MLL1 complex H3K4 methyltransferase activity.

Chemical Structure

DDO-2117

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565239

Name: DDO-2117

CAS#: NONE

Chemical Formula: C29H34ClFN6O2

Exact Mass: 552.2416

Molecular Weight: 553.08

Elemental Analysis: C, 62.98; H, 6.20; Cl, 6.41; F, 3.44; N, 15.20; O, 5.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DDO 2117; DDO2117; DDO-2117

IUPAC/Chemical Name

5-Amino-N-(4'-(4-aminobutanamido)-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl)-2-chloro-4-fluoro-3-methylbenzamide

InChi Key

PVXYYWORFYROCX-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H34ClFN6O2/c1-18-27(30)22(17-23(33)28(18)31)29(39)35-24-16-20(7-10-25(24)37-14-12-36(2)13-15-37)19-5-8-21(9-6-19)34-26(38)4-3-11-32/h5-10,16-17H,3-4,11-15,32-33H2,1-2H3,(H,34,38)(H,35,39)

SMILES Code

O=C(NC1=CC(C2=CC=C(NC(CCCN)=O)C=C2)=CC=C1N3CCN(C)CC3)C4=CC(N)=C(F)C(C)=C4Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 553.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li DD, Chen WL, Wang ZH, Xie YY, Xu XL, Jiang ZY, Zhang XJ, You QD, Guo XK. High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity. Eur J Med Chem. 2016 Nov 29;124:480-489. doi: 10.1016/j.ejmech.2016.08.036. Epub 2016 Aug 20. PubMed PMID: 27598236.