FL-411 is a potent and selective BRD4 inhibitor. FL411 was discovered to induce ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and thus activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells. FL411 displayed a therapeutic potential on both breast cancer xenograft mouse and zebrafish models. .
MedKoo Cat#: 462472
Name: FL411
CAS#: 2118944-88-8
Chemical Formula: C18H19N3O2S
Exact Mass: 341.1200
Molecular Weight: 341.43
Elemental Analysis: C, 63.32; H, 5.61; N, 12.31; O, 9.37; S, 9.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.4 | 15.82 |
The following data is based on the product molecular weight 341.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
