MDK0403, also known as B-Raf inhibitor 1, is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively. MDK0403 has CAS#1093100-40-03. The last 4 digit of CAS# was used for name for the convenience of scientific communication.
MedKoo Cat#: 407220
Name: MDK0403
CAS#: 1093100-40-3
Chemical Formula: C26H19ClN8
Exact Mass: 478.1421
Molecular Weight: 478.94
Elemental Analysis: C, 65.20; H, 4.00; Cl, 7.40; N, 23.40
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 73.0 | 152.42 |
The following data is based on the product molecular weight 478.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
