VHL-7526 TFA, also known as Protein Degrader 1 TFA, is a small-molecule ligand that recruits the von Hippel-Lindau (VHL) protein, an E3 ubiquitin ligase, facilitating targeted protein degradation via the ubiquitin-proteasome system. This compound serves as a building block in the development of proteolysis-targeting chimeras (PROTACs), which are bifunctional molecules designed to selectively degrade specific proteins by linking an E3 ligase ligand to a target protein ligand.
MedKoo Cat#: 407988
Name: VHL-7526 TFA
CAS#: 1631137-51-3 (TFA)
Chemical Formula: C24H31F3N4O5S
Exact Mass: 0.0000
Molecular Weight: 544.59
Elemental Analysis: C, 52.93; H, 5.74; F, 10.47; N, 10.29; O, 14.69; S, 5.89
The following data is based on the product molecular weight 544.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
