TAK-915 is a Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. TAK-915 showed PDE2A IC50: 0.61 nM; PDE selectivity: 4100 X (vs PDE1A); TPSA: 102; MDR` ratio: 0.87. TAK-915 demonstrates an appropriate combination of potency, PDE selectivity, and favorable pharmacokinetic (PK) properties, including brain penetration. Oral administration of TAK-915 demonstrated significant elevation of 3′,5′-cyclic guanosine monophosphate (cGMP) levels in mouse brains and improved cognitive performance in a novel object recognition task inrats. TAK-915 was advanced into human clinical trials.
MedKoo Cat#: 530906
Name: TAK-915
CAS#: 1476727-50-0
Chemical Formula: C19H18F4N4O5
Exact Mass: 458.1213
Molecular Weight: 458.37
Elemental Analysis: C, 49.79; H, 3.96; F, 16.58; N, 12.22; O, 17.45
The following data is based on the product molecular weight 458.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
