Guanethidine | CAS#55-65-2 | Antihypertensive

MedKoo Cat#: 584905 | Name: Guanethidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Guanethidine is an antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves.

Chemical Structure

Guanethidine

CAS#55-65-2 (free base)

Theoretical Analysis

MedKoo Cat#: 584905

Name: Guanethidine

CAS#: 55-65-2 (free base)

Chemical Formula: C10H22N4

Exact Mass: 198.1844

Molecular Weight: 198.31

Elemental Analysis: C, 60.57; H, 11.18; N, 28.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

55-65-2 (free base) 645-43-2 (sulfate) 60-02-6 (hemisulfate)

Synonym

Guanethidine; Octatensine; Dopam; Oktadin; Abapresin; Sanotensin

IUPAC/Chemical Name

Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-

InChi Key

ACGDKVXYNVEAGU-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)

SMILES Code

NC(NCCN1CCCCCCC1)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 198.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Freis ED. Guanethidine. Prog Cardiovasc Dis. 1965 Sep;8(2):183-93. PubMed PMID: 5826801. 2: Gerkens JF, McCulloch MW. Mechanism of the antagonism between guanethidine and dexamphetamine. Br J Pharmacol. 1969 Mar;35(3):563-72. PubMed PMID: 5809745; PubMed Central PMCID: PMC1703372. 3: Boullin DJ, O'Brien RA. The accumulation of guanethidine by human blood platelets. Br J Pharmacol. 1969 Jan;35(1):90-102. PubMed PMID: 5762045; PubMed Central PMCID: PMC1703085. 4: Cheng JT, Wang CJ, Hsu FL. Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats. Clin Exp Pharmacol Physiol. 1999 Oct;26(10):815-6. PubMed PMID: 10549407. 5: Sah HJ, Sah PP, Peoples SA. The new antihypertensive agent, guanethidine--a review. I. Discovery and development-chemical structure-physical properties-pharmacological actions. Arzneimittelforschung. 1966 Jan;16(1):53-8. Review. PubMed PMID: 4860825. 6: Shand DG, Morgan DH, Oates JA. The release of guanethidine and bethanidine by splenic nerve stimulation: a quantitative evaluation showing dissociation from adrenergic blockade. J Pharmacol Exp Ther. 1973 Jan;184(1):73-80. PubMed PMID: 4686017.