HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant. HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.
MedKoo Cat#: 555506
Name: HG-10-102-01
CAS#: 1351758-81-0
Chemical Formula: C17H20ClN5O3
Exact Mass: 377.1255
Molecular Weight: 377.83
Elemental Analysis: C, 54.04; H, 5.34; Cl, 9.38; N, 18.54; O, 12.70
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 10.0 | 26.47 | |
| DMSO | 40.0 | 105.87 | |
| DMSO:PBS (pH 7.2) (1:4) | 0.2 | 0.53 | |
| Ethanol | 0.3 | 0.79 |
The following data is based on the product molecular weight 377.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
