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MedKoo Cat#: 461397 | Name: Ormetoprim
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ormetoprim is an antibiotic approved for use in the United States used in combination with sulfadimethoxine to treat bacterial infections in fish farming.

Chemical Structure

Ormetoprim
Ormetoprim
CAS#6981-18-6

Theoretical Analysis

MedKoo Cat#: 461397

Name: Ormetoprim

CAS#: 6981-18-6

Chemical Formula: C14H18N4O2

Exact Mass: 274.1430

Molecular Weight: 274.32

Elemental Analysis: C, 61.30; H, 6.61; N, 20.42; O, 11.66

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 2 Weeks
1g USD 450.00 2 Weeks
5g USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Ormetoprim; Ro 5-9754; Ro-5-9754; Ro5-9754;
IUPAC/Chemical Name
5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine
InChi Key
KEEYRKYKLYARHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18)
SMILES Code
NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C)C(N)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 0.0 0.04
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 274.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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Vet Sci. 2022 Mar 25;9(4):159. doi: 10.3390/vetsci9040159. PMID: 35448657; PMCID: PMC9031543. 4: Wang L, Niu J, Wei P, Feng Y, Ding M, He C, Ma Y, Zhu Y, Li J, Huang L, Zhang X. Rapid determination of 2,4-diaminopyrimidine residues through sample pretreatment using immunomagnetic bead purification along with HPLC-UV. Food Chem. 2022 May 15;376:131835. doi: 10.1016/j.foodchem.2021.131835. Epub 2021 Dec 11. PMID: 34980530. 5: Han X, Sheng F, Kong D, Wang Y, Pan Y, Chen M, Tao Y, Liu Z, Ahmed S, Yuan Z, Peng D. Broad-spectrum monoclonal antibody and a sensitive multi-residue indirect competitive enzyme-linked immunosorbent assay for the antibacterial synergists in samples of animal origin. Food Chem. 2019 May 15;280:20-26. doi: 10.1016/j.foodchem.2018.12.040. Epub 2018 Dec 17. PMID: 30642487. 6: Van Vliet D, Loch TP, Smith P, Faisal M. Antimicrobial Susceptibilities of Flavobacterium psychrophilum Isolates from the Great Lakes Basin, Michigan. Microb Drug Resist. 2017 Sep;23(6):791-798. doi: 10.1089/mdr.2016.0103. Epub 2017 Jan 9. PMID: 28068184. 7: Fais AP, Franco RS, da Silva AF, de Freitas O, Paschoal JA. LC-MS/MS methods for sulfadimethoxine and ormetoprim analysis in feed and fish fillet and a leaching study for feed after alternative procedures for the incorporation of drugs. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Apr;34(4):501-508. doi: 10.1080/19440049.2016.1267875. Epub 2016 Dec 16. PMID: 27915582. 8: McDermott AJ, Field CL, Hoopes LA, Clauss TM. MEDICAL MANAGEMENT OF COELOMIC DISTENTION, ABNORMAL SWIMMING, SUBSTRATE RETENTION, AND HEMATOLOGIC CHANGES IN A REEF MANTA RAY (MANTA ALFREDI). J Zoo Wildl Med. 2016 Sep;47(3):927-930. doi: 10.1638/2015-0187.1. PMID: 27691938. 9: Soto E, Halliday-Simmonds I, Francis S, Fraites T, Martínez-López B, Wiles J, Hawke JP, Endris RD. Improved Broth Microdilution Method for Antimicrobial Susceptibility Testing of Francisella Noatunensis Orientalis. J Aquat Anim Health. 2016 Sep;28(3):199-207. doi: 10.1080/08997659.2016.1185051. PMID: 27484609. 10: Yang YJ, Liu XW, Li B, Li SH, Kong XJ, Qin Z, Li JY. Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry. Food Chem. 2016 Dec 1;212:358-66. doi: 10.1016/j.foodchem.2016.05.184. Epub 2016 Jun 1. PMID: 27374543. 11: Chuah LO, Effarizah ME, Goni AM, Rusul G. Antibiotic Application and Emergence of Multiple Antibiotic Resistance (MAR) in Global Catfish Aquaculture. Curr Environ Health Rep. 2016 Jun;3(2):118-27. doi: 10.1007/s40572-016-0091-2. PMID: 27038482. 12: Gieseker CM, Crosby TC, Mayer TD, Bodeis SM, Stine CB. Development of Similar Broth Microdilution Methods to Determine the Antimicrobial Susceptibility of Flavobacterium columnare and F. psychrophilum. J Aquat Anim Health. 2016 Mar;28(1):27-38. doi: 10.1080/08997659.2015.1105878. PMID: 26949840. 13: Smith P, Endris R, Kronvall G, Thomas V, Verner-Jeffreys D, Wilhelm C, Dalsgaard I. Epidemiological cut-off values for Flavobacterium psychrophilum MIC data generated by a standard test protocol. J Fish Dis. 2016 Feb;39(2):143-54. doi: 10.1111/jfd.12336. Epub 2014 Dec 26. PMID: 25546427. 14: Done HY, Halden RU. Reconnaissance of 47 antibiotics and associated microbial risks in seafood sold in the United States. J Hazard Mater. 2015 Jan 23;282:10-7. doi: 10.1016/j.jhazmat.2014.08.075. Epub 2014 Oct 5. PMID: 25449970; PMCID: PMC4254636. 15: Gieseker CM, Mayer TD, Crosby TC, Carson J, Dalsgaard I, Darwish AM, Gaunt PS, Gao DX, Hsu HM, Lin TL, Oaks JL, Pyecroft M, Teitzel C, Somsiri T, Wu CC. Quality control ranges for testing broth microdilution susceptibility of Flavobacterium columnare and F. psychrophilum to nine antimicrobials. Dis Aquat Organ. 2012 Nov 19;101(3):207-15. doi: 10.3354/dao02527. PMID: 23324417. 16: Declercq AM, Boyen F, Van den Broeck W, Bossier P, Karsi A, Haesebrouck F, Decostere A. Antimicrobial susceptibility pattern of Flavobacterium columnare isolates collected worldwide from 17 fish species. J Fish Dis. 2013 Jan;36(1):45-55. doi: 10.1111/j.1365-2761.2012.01410.x. Epub 2012 Sep 7. PMID: 22957716. 17: Guerard JJ, Chin YP. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3;60(39):9801-6. doi: 10.1021/jf302564d. Epub 2012 Sep 24. PMID: 22950359. 18: Summers JF, Brodbelt DC, Forsythe PJ, Loeffler A, Hendricks A. The effectiveness of systemic antimicrobial treatment in canine superficial and deep pyoderma: a systematic review. Vet Dermatol. 2012 Aug;23(4):305-29, e61. doi: 10.1111/j.1365-3164.2012.01050.x. Epub 2012 Jun 27. PMID: 22734856. 19: Hesami S, Parkman J, MacInnes JI, Gray JT, Gyles CL, Lumsden JS. Antimicrobial susceptibility of Flavobacterium psychrophilum isolates from Ontario. J Aquat Anim Health. 2010 Mar;22(1):39-49. doi: 10.1577/H09-008.1. PMID: 20575364. 20: Guerard JJ, Chin YP, Mash H, Hadad CM. Photochemical fate of sulfadimethoxine in aquaculture waters. Environ Sci Technol. 2009 Nov 15;43(22):8587-92. doi: 10.1021/es9020537. PMID: 20028056.