MedKoo Cat#: 555503 | Name: BMS-200

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 80 nM.

Chemical Structure

BMS-200
BMS-200
CAS#1675203-82-3

Theoretical Analysis

MedKoo Cat#: 555503

Name: BMS-200

CAS#: 1675203-82-3

Chemical Formula: C27H27F2NO6

Exact Mass: 499.1806

Molecular Weight: 499.51

Elemental Analysis: C, 64.92; H, 5.45; F, 7.61; N, 2.80; O, 19.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
BMS-200; BMS 200; BMS200;
IUPAC/Chemical Name
(S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2,5-difluorobenzyl)amino)-3-hydroxybutanoic acid
InChi Key
UUBRFEROHJGRBO-FQEVSTJZSA-N
InChi Code
InChI=1S/C27H27F2NO6/c1-16-18(3-2-4-21(16)17-5-6-24-26(10-17)35-8-7-34-24)15-36-25-12-22(28)19(9-23(25)29)13-30-14-20(31)11-27(32)33/h2-6,9-10,12,20,30-31H,7-8,11,13-15H2,1H3,(H,32,33)/t20-/m0/s1
SMILES Code
O=C(O)C[C@H](O)CNCC1=CC(F)=C(OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)C=C1F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 499.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of [1,2,4]Triazolo[4,3-a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Mingze Qin, Qi Cao, Shuaishuai Zheng, Ye Tian, Haotian Zhang, Jun Xie, Hongbo Xie, Yajing Liu, Yanfang Zhao, and Ping Gong Publication Date (Web): April 9, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00312