Related CAS #
16378-21-5 (free base); 16378-22-6 (HCl)
Synonym
Piroheptine HCl; Piroheptine Hydrochloride; Trimol;
IUPAC/Chemical Name
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-1-ethyl-2-methylpyrrolidine hydrochloride
InChi Key
PLJNHZOEOXGWIR-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25N.ClH/c1-3-23-15-14-19(16(23)2)22-20-10-6-4-8-17(20)12-13-18-9-5-7-11-21(18)22;/h4-11,16H,3,12-15H2,1-2H3;1H
SMILES Code
CCN1C(C)/C(CC1)=C2C(C=CC=C3)=C3CCC4=C\2C=CC=C4.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
339.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Katayama S, Ishizaki F, Yamamura Y, Khoriyama T, Kito S. Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain. Res Commun Chem Pathol Pharmacol. 1990 Sep;69(3):261-70. PubMed PMID: 2236897.
2: Otani K, Hirano T, Kondo T, Kaneko S, Fukushima Y, Noda K, Tashiro Y. Biperiden and piroheptine do not affect the serum level of zotepine, a new antipsychotic drug. Br J Psychiatry. 1990 Jul;157:128-30. PubMed PMID: 1975759.
3: Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. PubMed PMID: 3258627.
4: Ohashi T, Akita H, Tamura T, Noda K, Honda F. Effect of piroheptine, a new antiparkinson drug, on dopamine uptake into synaptosomes from corpus striatum of rat brain. Arzneimittelforschung. 1972 Jun;22(6):966-72. PubMed PMID: 5068358.
5: Hitomi M, Kumadaki N, Furukawa T, Ito N, Sato Y, Kumada S. Pharmacological study of piroheptine, a new antiparkinson drug, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidin e. I. Effects on drug-induced tremor and catatonia, and on adrenergic actions. Arzneimittelforschung. 1972 Jun;22(6):953-61. PubMed PMID: 4626187.
6: Hitomi M, Watanabe N, Kumadaki N, Kumada S. Pharmacological study of piroheptine, a new antiparkinson drug. II. Anticholinergic, antihistaminic, and psychopharmacological actions and toxicity. Arzneimittelforschung. 1972 Jun;22(6):961-6. PubMed PMID: 4403219.
