MedKoo Cat#: 584880 | Name: NA 0345

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NA 0345 is a SF 2370 derivative that produces a selective inhibition of the alpha 1-mediated PIE, probably through inhibition of the alpha 1-adrenoceptor-mediated activation of PKC.

Chemical Structure

NA 0345
NA 0345
CAS#120925-60-2

Theoretical Analysis

MedKoo Cat#: 584880

Name: NA 0345

CAS#: 120925-60-2

Chemical Formula: C27H26N4O3

Exact Mass: 454.2005

Molecular Weight: 454.53

Elemental Analysis: C, 71.35; H, 5.77; N, 12.33; O, 10.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NA 0345; NA-0345; NA0345
IUPAC/Chemical Name
9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-10-((methylamino)methyl)-, (9S-(9alpha,10beta,12alpha))-
InChi Key
NCSMUKLSRPWCNB-RJNNFIAUSA-N
InChi Code
InChI=1S/C27H26N4O3/c1-27-9-4-10-30-19-5-3-6-21(32)24(19)23-18-13-29-12-17(18)22-16-8-7-15(34-27)11-20(16)31(27,33,14-28-2)26(22)25(23)30/h4-5,7-9,12-13,15,28,33H,3,6,10-11,14H2,1-2H3/b9-4-/t15-,27+/m1/s1
SMILES Code
O=C(CCC=C12)C1=C3C4=CN=CC4=C5C6=C3N2C/C=C\[C@@](O7)(C)N6(CNC)(O)C8=C5C=C[C@]7([H])C8
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Endoh M, Norota I, Takanashi M, Kasai H. Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors. Jpn J Pharmacol. 1993 Sep;63(1):17-26. PubMed PMID: 8271527. 2: Souhrada M, Souhrada JF. The role of protein kinase-C in sensitization and antigen response of airway smooth muscle. Am Rev Respir Dis. 1989 Dec;140(6):1567-72. PubMed PMID: 2604287. 3: Endoh M. Cardiac alpha(1)-adrenoceptors that regulate contractile function: subtypes and subcellular signal transduction mechanisms. Neurochem Res. 1996 Feb;21(2):217-29. Review. PubMed PMID: 9182246. 4: Okagaki T, Ishikawa R, Kohama K. Inhibitory Ca(2+)-regulation of myosin light chain kinase in the lower eukaryote, Physarum polycephalum: role of a Ca(2+)-dependent inhibitory factor. Eur J Cell Biol. 1991 Oct;56(1):113-22. PubMed PMID: 1666040. 5: Hachisu M, Hiranuma T, Koyama M, Sezaki M. Antihypertensive compounds with potent protein kinases inhibitory activity. Life Sci. 1989;44(19):1351-62. PubMed PMID: 2765030. 6: Souhrada M, Souhrada JF. Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells. Am Rev Respir Dis. 1993 Aug;148(2):425-30. PubMed PMID: 8342907.