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MedKoo Cat#: 584522 | Name: Kri 1177

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kri 1177 inhibits renin activity thereby producing hypotension.

Chemical Structure

Kri 1177
Kri 1177
CAS#105186-68-3

Theoretical Analysis

MedKoo Cat#: 584522

Name: Kri 1177

CAS#: 105186-68-3

Chemical Formula: C37H45N5O6

Exact Mass: 655.3370

Molecular Weight: 655.80

Elemental Analysis: C, 67.77; H, 6.92; N, 10.68; O, 14.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Kri 1177; Kri-1177; Kri1177
IUPAC/Chemical Name
Hexanoic acid, 2-hydroxy-3-((3-(1H-imidazol-4-yl)-2-((2-(1-naphthalenylmethyl)-1,4-dioxo-4-((2-phenylethyl)amino)butyl)amino)-1-oxopropyl)amino)-5-methyl-, methyl ester
InChi Key
UQUFRFSCUYVXBM-UHFFFAOYSA-N
InChi Code
InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
SMILES Code
CC(C)CC(NC(C(NC(C(CC1=C2C=CC=CC2=CC=C1)CC(NCCC3=CC=CC=C3)=O)=O)CC4=CNC=N4)=O)C(O)C(OC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 655.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Toda N, Miyazaki M, Etoh Y, Kubota T, Iizuka K. Human renin inhibiting dipeptide. Eur J Pharmacol. 1986 Oct 7;129(3):393-6. PubMed PMID: 3536533. 2: Iizuka K, Kamijo T, Kubota T, Akahane K, Umeyama H, Kiso Y. New human renin inhibitors containing an unnatural amino acid, norstatine. J Med Chem. 1988 Apr;31(4):701-4. PubMed PMID: 3127587.