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MedKoo Cat#: 584877 | Name: Clenbuterol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clenbuterol is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator in the treatment of pulmonary diseases such as asthma. At higher doses, clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition. Clenbuterol, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice. Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. Clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats.

Chemical Structure

Clenbuterol
Clenbuterol
CAS#37148-27-9 (free base)

Theoretical Analysis

MedKoo Cat#: 584877

Name: Clenbuterol

CAS#: 37148-27-9 (free base)

Chemical Formula: C12H18Cl2N2O

Exact Mass: 276.0796

Molecular Weight: 277.19

Elemental Analysis: C, 52.00; H, 6.55; Cl, 25.58; N, 10.11; O, 5.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
37148-27-9 (free base) 21898-19-1 (HCl)
Synonym
Clenbuterol; NAB 365; NAB365; NAB-365; P 5369; P-5369; P5369; Planipart
IUPAC/Chemical Name
4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcoho
InChi Key
STJMRWALKKWQGH-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3
SMILES Code
ClC1=C(N)C(Cl)=CC(C(O)CNC(C)(C)C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahn V, Krumbachner G. Clenbuterol - A long term uterine relaxant. J Perinat Med. 2023 Nov 2;9(2):96-100. doi: 10.1515/jpm-1981-090201. PMID: 37909793. 2: Lin YW, Fang CH, Liang YJ, Yang CY, Kuo WT, Lin FH. Controlled release of Clenbuterol from a hydroxyapatite carrier for the treatment of Alzheimer's Disease. Biomater Res. 2023 Oct 5;27(1):98. doi: 10.1186/s40824-023-00432-4. PMID: 37798744; PMCID: PMC10557233. 3: Hu D, Li H, Yu H, Zhao M, Ye L, Liu B, Ge N, Dong N, Wu L. Clenbuterol Prevents Mechanical Unloading-Induced Myocardial Atrophy via Upregulation of Transient Receptor Potential Channel-3. Int Heart J. 2023;64(5):901-909. doi: 10.1536/ihj.21-129. PMID: 37778993. 4: Gibbs RL, Swanson RM, Beard JK, Hicks ZM, Most MS, Beer HN, Grijalva PC, Clement SM, Marks-Nelson ES, Schmidt TB, Petersen JL, Yates DT. Daily injection of the β2 adrenergic agonist clenbuterol improved poor muscle growth and body composition in lambs following heat stress-induced intrauterine growth restriction. Front Physiol. 2023 Sep 6;14:1252508. doi: 10.3389/fphys.2023.1252508. PMID: 37745251; PMCID: PMC10516562. 5: Saito K, Ito R, Ohsawa Y. Development of a Solid-Phase Dispersive Extraction Method for Molecularly Imprinted Polymers and LC-MS/MS for Analysis of Clenbuterol Residues in Swine Livers and Kidneys. J AOAC Int. 2023 Nov 2;106(6):1701-1705. doi: 10.1093/jaoacint/qsad095. PMID: 37603714. 6: Guo Q, Peng Y, Chao K, Qin J, Chen Y, Yin T. A determination method for clenbuterol residue in pork based on optimal particle size gold colloid using SERS. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Dec 5;302:123097. doi: 10.1016/j.saa.2023.123097. Epub 2023 Jul 1. PMID: 37418907. 7: Zhang J, Lu J, Zhang Y, Wang Y. A LC-MS/MS method for determination of clenbuterol enantiomers in animal tissues and its application to the enantioselective distribution in Bama mini-pigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 15;1226:123790. doi: 10.1016/j.jchromb.2023.123790. Epub 2023 Jun 14. PMID: 37329777. 8: Jigyasa, Kaur Rajput J. Nanosensors: A smart remedy for early detection of clenbuterol contamination in food. Food Chem. 2023 Nov 15;426:136569. doi: 10.1016/j.foodchem.2023.136569. Epub 2023 Jun 7. PMID: 37302312. 9: Li X, Koeberl DD, Lutz MW, Bedlack R. Clenbuterol Treatment Is Safe and Associated With Slowed Disease Progression in a Small Open-Label Trial in Patients With Amyotrophic Lateral Sclerosis. J Clin Neuromuscul Dis. 2023 Jun 1;24(4):214-221. doi: 10.1097/CND.0000000000000438. PMID: 37219865. 10: Cai L, Wang H, Cao Y, Hao W, Fang G, Wang S. "Blocking-effect" detection strategy of clenbuterol by molecularly imprinted electrochemiluminescence sensor based on multiple synergistic excitation of AgNW luminophores signal with highly active BNQDs@AuNFs nanoscale co-reaction accelerator. Biosens Bioelectron. 2023 Aug 15;234:115336. doi: 10.1016/j.bios.2023.115336. Epub 2023 Apr 27. PMID: 37126875. 11: Kumari S, Pal B, Sahu SK, Prabhakar PK, Tewari D. Adverse events of clenbuterol among athletes: a systematic review of case reports and case series. Int J Legal Med. 2023 Jul;137(4):1023-1037. doi: 10.1007/s00414-023-02996-1. Epub 2023 Apr 17. PMID: 37062796. 12: Tien VM, Ong VH, Pham TN, Quang Hoa N, Nguyen TL, Thang PD, Khanh Vinh L, Trinh PTN, Thanh DTN, Tung LM, Le AT. A molybdenum disulfide/nickel ferrite- modified voltammetric sensing platform for ultra-sensitive determination of clenbuterol under the presence of an external magnetic field. RSC Adv. 2023 Apr 3;13(16):10577-10591. doi: 10.1039/d3ra01136d. PMID: 37021107; PMCID: PMC10069232. 13: Velasco-Bejarano B, Espinoza-Muñoz IM, Álvarez-Sánchez A, Gómez-Tagle A, Velasco-Carrillo R, Bautista J, Rodríguez L. Quantification and enantiomeric distribution of clenbuterol in several bovine tissues using UHPLC-tandem mass spectrometry: Evaluation of a risk factor associated with meat contamination. Drug Test Anal. 2023 Jun;15(6):646-653. doi: 10.1002/dta.3464. Epub 2023 Mar 14. PMID: 36843387. 14: Li F, Zhou J, Wang M, Zhang L, Yang M, Deng L. Production of a matrix certified reference material for measurement and risk monitoring of clenbuterol in mutton. Anal Bioanal Chem. 2023 Mar;415(8):1487-1496. doi: 10.1007/s00216-023-04543-8. Epub 2023 Feb 3. PMID: 36732370. 15: Xiao S, Sun L, Kang M, Dong Z. A label-free aptasensor for clenbuterol detection based on fluorescence resonance energy transfer between graphene oxide and rhodamine B. RSC Adv. 2022 Nov 15;12(50):32737-32743. doi: 10.1039/d2ra06260g. PMID: 36425698; PMCID: PMC9664316. 16: Guo Q, Peng Y, Zhao X, Chen Y. Rapid Detection of Clenbuterol Residues in Pork Using Enhanced Raman Spectroscopy. Biosensors (Basel). 2022 Oct 11;12(10):859. doi: 10.3390/bios12100859. PMID: 36290996; PMCID: PMC9599483. 17: Wu T, Li J, Zheng S, Yu Q, Qi K, Shao Y, Wang C, Tu J, Xiao R. Magnetic Nanotag-Based Colorimetric/SERS Dual-Readout Immunochromatography for Ultrasensitive Detection of Clenbuterol Hydrochloride and Ractopamine in Food Samples. Biosensors (Basel). 2022 Sep 1;12(9):709. doi: 10.3390/bios12090709. PMID: 36140094; PMCID: PMC9496078. 18: Rankins EM, Salem K, Manso Filho HC, Malinowski K, McKeever KH. Effect of Clenbuterol on Muscle Activity During Exercise in Standardbred Horses. J Equine Vet Sci. 2022 Nov;118:104126. doi: 10.1016/j.jevs.2022.104126. Epub 2022 Sep 15. PMID: 36115549. 19: Li Y, Zhang H, Cui Z, Liu S, Xu J, Jia C, Chen Y, Wang L, Sun J, Zhang D, Zhu M, Wang J. Chemical staining enhanced Enzyme-linked immunosorbent assay for sensitive determination of Clenbuterol in food. Food Chem. 2023 Jan 30;400:134012. doi: 10.1016/j.foodchem.2022.134012. Epub 2022 Aug 27. PMID: 36055143. 20: Wan L, Gao H, Liu X, Gao S, Zhou L, Wang F, Chen M. Electromembrane extraction of clenbuterol from swine urine for monitoring illegal use in livestock. J Sep Sci. 2022 Nov;45(21):3966-3973. doi: 10.1002/jssc.202200469. Epub 2022 Sep 4. PMID: 36040857.