Synonym
AH 23848, AH23848, AH-23848, AH 23848B, AH23848B, AH-23848B
IUPAC/Chemical Name
4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-, (1-alpha(Z),2-beta,5-alpha)-(+-)-
InChi Key
IOFUFYLETVNNRF-FKQKSGFWSA-N
InChi Code
1S/C29H35NO5/c31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30/h1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33)/b2-1-/t25-,27-,29+/m1/s1
SMILES Code
OC(=O)CC\C=C/CC[C@@H]1[C@@H](CC(=O)[C@H]1N2CCOCC2)OCc3ccc(cc3)c4ccccc4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
477.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lin YS, Hsieh M, Lee YJ, Liu KL, Lin TH. AH23848 accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells. Nitric Oxide. 2008 Mar;18(2):93-104. Epub 2007 Nov 6. PubMed PMID: 18039475.
2: Arner M, Högestätt ED, Uski TK. Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM13,505 and AH23848. Acta Physiol Scand. 1991 Jan;141(1):79-86. PubMed PMID: 2053448.
3: Lane IF, Lumley P, Michael MF, Peters AM, McCollum CN. A specific thromboxane receptor blocking drug, AH23848, reduces platelet deposition on vascular grafts in man. Thromb Haemost. 1990 Nov 30;64(3):369-73. PubMed PMID: 2151407.
4: De Bono DP, Lumley P, Been M, Keery R, Ince SE, Woodings DF. Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris. Br Heart J. 1986 Dec;56(6):509-17. PubMed PMID: 2948534; PubMed Central PMCID: PMC1216397.
5: Brittain RT, Boutal L, Carter MC, Coleman RA, Collington EW, Geisow HP, Hallett P, Hornby EJ, Humphrey PP, Jack D, et al. AH23848: a thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2. Circulation. 1985 Dec;72(6):1208-18. PubMed PMID: 2998642.
6: Coker SJ, Parratt JR. AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion-induced arrhythmias in anaesthetized greyhounds. Br J Pharmacol. 1985 Sep;86(1):259-64. PubMed PMID: 3840397; PubMed Central PMCID: PMC1916881.
