Sekdel sequence | CAS#123924-38-9 | signal

MedKoo Cat#: 597467 | Name: Sekdel sequence

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sekdel sequence is a signal which leads to retention of at least two proteins in the endoplasmic reticulum of animal cells.

Chemical Structure

Sekdel sequence

CAS#123924-38-9

Theoretical Analysis

MedKoo Cat#: 597467

Name: Sekdel sequence

CAS#: 123924-38-9

Chemical Formula: C29H49N7O14

Exact Mass: 719.3337

Molecular Weight: 719.74

Elemental Analysis: C, 48.39; H, 6.86; N, 13.62; O, 31.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sekdel sequence; Ser-glu-lys-asp-glu-leu; Seryl-glutamyl-lysyl-aspartyl-glutamyl-leucine;

IUPAC/Chemical Name

(2S,5S,8S,11S,14S)-14-((S)-2-amino-3-hydroxypropanamido)-11-(4-aminobutyl)-5-(2-carboxyethyl)-8-(carboxymethyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid

InChi Key

BKWMKTIGFLPGOV-RABCQHRBSA-N

InChi Code

InChI=1S/C29H49N7O14/c1-14(2)11-20(29(49)50)36-27(47)18(7-9-22(40)41)34-28(48)19(12-23(42)43)35-25(45)16(5-3-4-10-30)33-26(46)17(6-8-21(38)39)32-24(44)15(31)13-37/h14-20,37H,3-13,30-31H2,1-2H3,(H,32,44)(H,33,46)(H,34,48)(H,35,45)(H,36,47)(H,38,39)(H,40,41)(H,42,43)(H,49,50)/t15-,16-,17-,18-,19-,20-/m0/s1

SMILES Code

CC(C)C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CO)N)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 719.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Biocca S, Tafani M, Cattaneo A. Assembled IgG molecules are exported from the endoplasmic reticulum in myeloma cells despite the retention signal SEKDEL. Biochem Biophys Res Commun. 1998 May 19;246(2):518-23. PubMed PMID: 9610394. 2: Zagouras P, Rose JK. Carboxy-terminal SEKDEL sequences retard but do not retain two secretory proteins in the endoplasmic reticulum. J Cell Biol. 1989 Dec;109(6 Pt 1):2633-40. PubMed PMID: 2592401; PubMed Central PMCID: PMC2115906. 3: zu Putlitz J, Skerra A, Wands JR. Intracellular expression of a cloned antibody fragment interferes with hepatitis B virus surface antigen secretion. Biochem Biophys Res Commun. 1999 Feb 24;255(3):785-91. PubMed PMID: 10049788. 4: Kim YS, Kim MY, Kim TG, Yang MS. Expression and assembly of cholera toxin B subunit (CTB) in transgenic carrot (Daucus carota L.). Mol Biotechnol. 2009 Jan;41(1):8-14. doi: 10.1007/s12033-008-9086-z. Epub 2008 Jul 19. PubMed PMID: 18642102. 5: Haq TA, Mason HS, Clements JD, Arntzen CJ. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science. 1995 May 5;268(5211):714-6. PubMed PMID: 7732379. 6: Tabe LM, Higgins CM, McNabb WC, Higgins TJ. Genetic engineering of grain and pasture legumes for improved nutritive value. Genetica. 1993;90(2-3):181-200. Review. PubMed PMID: 8119592. 7: Chong DK, Langridge WH. Expression of full-length bioactive antimicrobial human lactoferrin in potato plants. Transgenic Res. 2000 Feb;9(1):71-8. PubMed PMID: 10853271.